Royals vs. Padres Prediction: San Diego Predicted to Win Friday's MLB Matchup [6/20/2025]

The San Diego Padres and Kansas City Royals will meet in MLB action at PETCO Park on Friday, starting at 9:40PM ET.

The Padres will send Nick Pivetta (7-2, 3.40 ERA) to the mound, while the Royals are going with Michael Lorenzen (4-7, 4.91 ERA).

Based on updated simulation results, Dimers' proven MLB model (see Dimers Pro for full access) projects the Padres as the most likely winner of today's game.

"Employing the latest data, our experts simulated Friday's Royals-Padres game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"After computing the latest updates and thousands of other inputs, we predict the Padres' chance of winning is 59%, while the Royals' is 41%."

For expanded analysis of Friday's matchup, including best bets and picks, visit our interactive Royals vs. Padres predictions page.

Padres vs. Royals Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data, we have simulated the result of Friday's MLB game between the Royals and Padres 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Padres a 59% chance of beating the Royals.

According to our model, the Royals (+1.5) have a 59% chance of covering the run line, while the over/under total of 8 runs has a 53% chance of staying under.

Royals vs. Padres Odds [6/20/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Royals	Padres
Run Line	+1.5 (-154)	-1.5 (+135)
Moneyline	+141	-165
Total	o8 (-108)	u8 (-112)

All odds are correct at the time of publication and are subject to change.

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Royals vs. Padres Picks and Best Bets

Our model's strongest edge in today's Royals vs. Padres matchup is on the moneyline.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Royals vs. Padres Game-Day Updates and Essential Details

Friday's MLB game between the Padres and Royals at PETCO Park is scheduled to commence at 9:40PM ET.

• Who: Kansas City Royals vs. San Diego Padres
• Date: Friday, June 20, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: PETCO Park

Dimers.com's in-depth preview of Friday's Royals vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any Royals vs. Padres picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Padres, with a 59% win probability, will likely beat the Royals on Friday.

AI and automation have enhanced this article to quickly deliver accurate Royals vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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