Royals vs. Phillies prediction: Why Philadelphia is favored to win Friday's MLB matchup [9/12/2025]

The Philadelphia Phillies and Kansas City Royals are scheduled to meet in MLB action at Citizens Bank Park on Friday, starting at 6:45PM ET.

Walker Buehler (7-7, 5.45 ERA) will start for the Phillies, while the Royals have opted for Michael Lorenzen (5-10, 4.63 ERA).

Based on updated simulation results, Dimers' advanced MLB model projects the Phillies as the most likely winner of today's game.

For expanded analysis of Friday's matchup, including best bets and picks, visit our interactive Royals vs. Phillies predictions page.

Phillies vs. Royals prediction: Who will win, cover the run line?

Using trusted machine learning and statistical analysis, we have simulated the result of Friday's MLB game between the Royals and Phillies 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Phillies a 55% chance of beating the Royals.

According to our model, the Royals (+1.5) have a 62% chance of covering the run line, while the 9-run over/under has a 55% chance of going over.

Royals vs. Phillies odds [9/12/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Royals	Phillies
Run Line	+1.5 (-173)	-1.5 (+146)
Moneyline	+120	-140
Total	o9 (-113)	u9 (+100)

All odds are correct at the time of publication and are subject to change.

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Royals vs. Phillies picks and best bets

Our model's strongest edge in today's Royals vs. Phillies matchup is on the run line.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

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Royals vs. Phillies game-day updates and essential details

Friday's MLB action between the Phillies and Royals at Citizens Bank Park is scheduled to start at 6:45PM ET.

• Who: Kansas City Royals vs. Philadelphia Phillies
• Date: Friday, September 12, 2025
• Time: 6:45PM ET/3:45PM PT
• Venue: Citizens Bank Park

Dimers' in-depth preview of Friday's Royals vs. Phillies matchup includes our prediction, picks and the latest betting odds.

Before making any Royals vs. Phillies picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Phillies, with a 55% win probability, will likely beat the Royals on Friday.

AI and automation have enhanced this article to quickly deliver accurate Royals vs. Phillies insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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