Royals vs. Angels prediction: Angels favored to win Wednesday's MLB matchup [9/24/2025]

The Los Angeles Angels and Kansas City Royals will lock horns in MLB action at Angel Stadium on Wednesday, starting at 9:38PM ET.

The Angels will start Yusei Kikuchi (6-11, 4.05 ERA), while the Royals have opted for Stephen Kolek (5-6, 3.54 ERA).

Based on updated simulations, Dimers' proven MLB model projects the Angels as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Royals-Angels game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Angels' chance of winning at 51%, with the Royals at 49%."

For expanded analysis of Wednesday's matchup, including best bets and picks, visit our interactive Royals vs. Angels predictions page.

Angels vs. Royals prediction: Who will win?

Using trusted machine learning and data, we have simulated the result of Wednesday's MLB game between the Royals and Angels 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Angels a 51% chance of defeating the Royals.

According to our model, the 8.5-run over/under has a 54% chance of going over.

Royals vs. Angels odds [9/24/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Royals	Angels
Moneyline	-108	-102
Total	o8.5 (-104)	u8.5 (-115)

All odds are correct at the time of publication and are subject to change.

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Royals vs. Angels picks and best bets

Our model's strongest edge in today's Royals vs. Angels matchup is on the moneyline.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Royals vs. Angels game-day updates and essential details

Wednesday's MLB action between the Angels and Royals at Angel Stadium is scheduled to commence at 9:38PM ET.

• Who: Kansas City Royals vs. Los Angeles Angels
• Date: Wednesday, September 24, 2025
• Time: 9:38PM ET/6:38PM PT
• Venue: Angel Stadium

Dimers' full preview of Wednesday's Royals vs. Angels matchup includes our prediction, picks and the latest betting odds.

Before making any Royals vs. Angels picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Plus, with sports betting in Missouri launching on December 1, 2025, Dimers has everything you need—from the latest updates and the best pre-registration offers in MO.

Conclusion

We predict the Angels, with a 51% win probability, will likely beat the Royals on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Royals vs. Angels insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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