Royals vs. Angels prediction: Kansas City favored to win Tuesday's MLB matchup [9/23/2025]

The Los Angeles Angels and Kansas City Royals will lock horns in MLB action at Angel Stadium on Tuesday, starting at 9:38PM ET.

Sam Aldegheri (0-0, 10.38 ERA) will get the ball for the Angels, while the Royals have opted for Cole Ragans (2-3, 5.16 ERA).

Based on the latest simulation results, Dimers' proven MLB model predicts the Royals as the most likely winner of today's game.

For expanded analysis of Tuesday's matchup, including best bets and picks, visit our interactive Royals vs. Angels predictions page.

Angels vs. Royals prediction: Who will win, cover the run line?

Using powerful machine learning and statistical analysis, we have simulated the outcome of Tuesday's MLB matchup between the Royals and Angels 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Royals a 58% chance of beating the Angels.

According to our model, the Angels (+1.5) have a 55% chance of covering the run line, while the 9-run over/under has a 53% chance of going over.

Royals vs. Angels odds [9/23/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Royals	Angels
Run Line	-1.5 (+100)	+1.5 (-115)
Moneyline	-165	+140
Total	o9 (-110)	u9 (-110)

All odds are correct at the time of publication and are subject to change.

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Royals vs. Angels picks and best bets

Our model's biggest edge in today's Royals vs. Angels matchup is on the over/under.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free ⚾️ picks

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Royals vs. Angels game-day updates and essential details

Tuesday's MLB action between the Angels and Royals at Angel Stadium is scheduled to start at 9:38PM ET.

• Who: Kansas City Royals vs. Los Angeles Angels
• Date: Tuesday, September 23, 2025
• Time: 9:38PM ET/6:38PM PT
• Venue: Angel Stadium

Dimers' in-depth preview of Tuesday's Royals vs. Angels matchup includes our prediction, picks and the latest betting odds.

Before making any Royals vs. Angels picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Royals, with a 58% win probability, will likely beat the Angels on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Royals vs. Angels insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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