Royals vs. Angels prediction: Kansas City favored to win Thursday's MLB matchup [9/25/2025]

The Los Angeles Angels will face the Kansas City Royals, in what is expected to be a tight MLB game, at Angel Stadium on Thursday, commencing at 9:38PM ET.

The Angels will start Mitch Farris (1-2, 6.52 ERA), up against Michael Lorenzen (6-11, 4.70 ERA) for the Royals.

Based on updated simulations, Dimers' advanced MLB model predicts the Royals as the most likely winner of today's game.

For a closer look at Thursday's matchup, including best bets and picks, visit our interactive Royals vs. Angels predictions page.

Angels vs. Royals prediction: Who will win, cover the run line?

Using innovative machine learning and data analysis, we have simulated the outcome of Thursday's MLB matchup between the Royals and Angels 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Royals a 54% chance of beating the Angels.

According to our model, the Angels (+1.5) have a 58% chance of covering the run line, while the over/under total of 9 runs has a 56% chance of going over.

Royals vs. Angels odds [9/25/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Royals	Angels
Run Line	-1.5 (+126)	+1.5 (-144)
Moneyline	-132	+115
Total	o9 (-118)	u9 (-102)

All odds are correct at the time of publication and are subject to change.

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Royals vs. Angels picks and best bets

Our model's strongest edge in today's Royals vs. Angels matchup is on the run line.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

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Royals vs. Angels game-day updates and essential details

Thursday's MLB matchup between the Angels and Royals at Angel Stadium is scheduled to begin at 9:38PM ET.

• Who: Kansas City Royals vs. Los Angeles Angels
• Date: Thursday, September 25, 2025
• Time: 9:38PM ET/6:38PM PT
• Venue: Angel Stadium

Dimers' in-depth preview of Thursday's Royals vs. Angels matchup includes our prediction, picks and the latest betting odds.

Before making any Royals vs. Angels picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Royals, with a 54% win probability, will likely beat the Angels on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Royals vs. Angels insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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