Royals vs. Tigers prediction: Detroit favored to win Friday's MLB matchup [8/22/2025]

The Detroit Tigers and Kansas City Royals will lock horns in MLB action at Comerica Park on Friday, starting at 7:10PM ET.

Casey Mize (12-4, 3.63 ERA) will start for the Tigers, up against Ryan Bergert (1-1, 2.75 ERA) for the Royals.

Based on updated simulation results, Dimers' proven MLB model projects the Tigers as the most likely winner of today's game.

For further insights into Friday's matchup, including best bets and picks, visit our interactive Royals vs. Tigers predictions page.

Tigers vs. Royals prediction: Who will win, cover the run line?

Using trusted machine learning and data analysis, we have simulated the result of Friday's MLB game between the Royals and Tigers 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Tigers a 59% chance of defeating the Royals.

According to our model, the Royals (+1.5) have a 60% chance of covering the run line, while the 8.5-run over/under has a 52% chance of going over.

Royals vs. Tigers odds [8/22/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Royals	Tigers
Run Line	+1.5 (-150)	-1.5 (+140)
Moneyline	+136	-160
Total	o8.5 (-113)	u8.5 (-105)

All odds are correct at the time of publication and are subject to change.

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Royals vs. Tigers picks and best bets

Our model's strongest edge in today's Royals vs. Tigers matchup is on the total.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

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Royals vs. Tigers game-day updates and essential details

Friday's MLB game between the Tigers and Royals at Comerica Park is scheduled to begin at 7:10PM ET.

• Who: Kansas City Royals vs. Detroit Tigers
• Date: Friday, August 22, 2025
• Time: 7:10PM ET/4:10PM PT
• Venue: Comerica Park

Dimers.com's comprehensive preview of Friday's Royals vs. Tigers matchup includes our prediction, picks and the latest betting odds.

Before making any Royals vs. Tigers picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Tigers, with a 59% win probability, will likely beat the Royals on Friday.

AI and automation have enhanced this article to quickly deliver accurate Royals vs. Tigers insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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