Royals vs. Guardians prediction: Why Cleveland is favored to win Wednesday's MLB matchup [9/10/2025]

MLB action continues on Wednesday at 6:40PM ET as the Kansas City Royals take on the Cleveland Guardians at Progressive Field.

Logan Allen (7-11, 4.46 ERA) will start for the Guardians, while the Royals are going with Jonathan Bowlan (1-2, 3.57 ERA).

Based on updated simulations, Dimers' advanced MLB model projects the Guardians as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Royals-Guardians game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Guardians' chance of winning at 51%, with the Royals at 49%."

For expanded analysis of Wednesday's matchup, including best bets and picks, visit our interactive Royals vs. Guardians predictions page.

Guardians vs. Royals prediction: Who will win?

Using innovative machine learning and data, we have simulated the result of Wednesday's MLB matchup between the Royals and Guardians 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Guardians a 51% chance of defeating the Royals.

According to our model, the 8-run over/under has a 53% chance of going over.

Royals vs. Guardians odds [9/10/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Royals	Guardians
Moneyline	-106	-110
Total	o8 (-107)	u8 (-110)

All odds are correct at the time of publication and are subject to change.

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Royals vs. Guardians picks and best bets

Our model's strongest edge in today's Royals vs. Guardians matchup is on the moneyline.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free ⚾️ picks

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Royals vs. Guardians game-day updates and essential details

Wednesday's MLB game between the Guardians and Royals at Progressive Field is scheduled to commence at 6:40PM ET.

• Who: Kansas City Royals vs. Cleveland Guardians
• Date: Wednesday, September 10, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: Progressive Field

Dimers' full preview of Wednesday's Royals vs. Guardians matchup includes our prediction, picks and the latest betting odds.

Before making any Royals vs. Guardians picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Guardians, with a 51% win probability, will likely beat the Royals on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Royals vs. Guardians insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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