Royals vs. Guardians prediction: Why Kansas City is favored to win Tuesday's MLB matchup [9/9/2025]

The Cleveland Guardians will face the Kansas City Royals in MLB action at Progressive Field on Tuesday, commencing at 6:40PM ET.

Joey Cantillo (4-3, 3.73 ERA) will start for the Guardians, pitting him against Noah Cameron (7-6, 3.03 ERA) for the Royals.

Based on updated simulations, Dimers' advanced MLB model predicts the Royals as the most likely winner of today's game.

For expanded analysis of Tuesday's matchup, including best bets and picks, visit our interactive Royals vs. Guardians predictions page.

Guardians vs. Royals prediction: Who will win, cover the run line?

Using trusted machine learning and data, we have simulated the outcome of Tuesday's MLB game between the Royals and Guardians 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Royals a 51% chance of defeating the Guardians.

According to our model, the Royals (+1.5) have a 68% chance of covering the run line, while the over/under total of 7.5 runs has a 51% chance of going over.

Royals vs. Guardians odds [9/9/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Royals	Guardians
Run Line	+1.5 (-225)	-1.5 (+170)
Moneyline	-105	-110
Total	o7.5 (-105)	u7.5 (-112)

All odds are correct at the time of publication and are subject to change.

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Royals vs. Guardians picks and best bets

Our model's biggest edge in today's Royals vs. Guardians matchup is on the moneyline.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free ⚾️ picks

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Royals vs. Guardians game-day updates and essential details

Tuesday's MLB action between the Guardians and Royals at Progressive Field is scheduled to begin at 6:40PM ET.

• Who: Kansas City Royals vs. Cleveland Guardians
• Date: Tuesday, September 9, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: Progressive Field

Dimers' in-depth preview of Tuesday's Royals vs. Guardians matchup includes our prediction, picks and the latest betting odds.

Before making any Royals vs. Guardians picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Royals, with a 51% win probability, will likely beat the Guardians on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Royals vs. Guardians insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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