Royals vs. Guardians prediction: Why Cleveland is favored to win Thursday's MLB matchup [9/11/2025]

The Cleveland Guardians and Kansas City Royals are scheduled to meet in MLB action at Progressive Field on Thursday, starting at 7:15PM ET.

The Guardians will have Gavin Williams (10-5, 3.17 ERA) as their starting pitcher, up against Stephen Kolek (5-5, 3.88 ERA) for the Royals.

Based on the latest simulation results, Dimers' advanced MLB model predicts the Guardians as the most likely winner of today's game.

For expanded analysis of Thursday's matchup, including best bets and picks, visit our interactive Royals vs. Guardians predictions page.

Guardians vs. Royals prediction: Who will win, cover the run line?

Using innovative machine learning and data, we have simulated the result of Thursday's MLB game between the Royals and Guardians 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Guardians a 55% chance of beating the Royals.

According to our model, the Royals (+1.5) have a 64% chance of covering the run line, while the 7.5-run over/under has a 53% chance of going over.

Royals vs. Guardians odds [9/11/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Royals	Guardians
Run Line	+1.5 (-187)	-1.5 (+158)
Moneyline	+122	-136
Total	o7.5 (-107)	u7.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Royals vs. Guardians picks and best bets

Our model's biggest edge in today's Royals vs. Guardians matchup is on the run line.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free ⚾️ picks

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Royals vs. Guardians game-day updates and essential details

Thursday's MLB matchup between the Guardians and Royals at Progressive Field is scheduled to commence at 7:15PM ET.

• Who: Kansas City Royals vs. Cleveland Guardians
• Date: Thursday, September 11, 2025
• Time: 7:15PM ET/4:15PM PT
• Venue: Progressive Field

Dimers' comprehensive preview of Thursday's Royals vs. Guardians matchup includes our prediction, picks and the latest betting odds.

Before making any Royals vs. Guardians picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Guardians, with a 55% win probability, will likely beat the Royals on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Royals vs. Guardians insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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