Royals vs. Cubs Prediction: Cubs Predicted to Win Wednesday's MLB Matchup [7/23/2025]

The Chicago Cubs and Kansas City Royals will meet in MLB action at Wrigley Field on Wednesday, starting at 2:20PM ET.

The Cubs will start Colin Rea (8-3, 3.80 ERA), while the Royals have opted for Seth Lugo (6-5, 2.94 ERA).

Based on updated simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Cubs as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Royals-Cubs game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Cubs' chance of winning at 57%, with the Royals at 43%."

For expanded analysis of Wednesday's matchup, including best bets and picks, visit our interactive Royals vs. Cubs predictions page.

Cubs vs. Royals Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and statistical analysis, we have simulated the result of Wednesday's MLB game between the Royals and Cubs 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Cubs a 57% chance of defeating the Royals.

According to our model, the Royals (+1.5) have a 60% chance of covering the run line, while the over/under total of 9.5 runs has a 51% chance of going over.

Royals vs. Cubs Odds [7/23/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Royals	Cubs
Run Line	+1.5 (-134)	-1.5 (+112)
Moneyline	+150	-171
Total	o9.5 (-124)	u9.5 (+102)

All odds are correct at the time of publication and are subject to change.

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Royals vs. Cubs Picks and Best Bets

Our model's biggest edge in today's Royals vs. Cubs matchup is on the moneyline.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the free picks featured below.

Royals vs. Cubs Game-Day Updates and Essential Details

Wednesday's MLB action between the Cubs and Royals at Wrigley Field is scheduled to begin at 2:20PM ET.

• Who: Kansas City Royals vs. Chicago Cubs
• Date: Wednesday, July 23, 2025
• Time: 2:20PM ET/11:20AM PT
• Venue: Wrigley Field

Dimers.com's in-depth preview of Wednesday's Royals vs. Cubs matchup includes our prediction, picks and the latest betting odds.

Before making any Royals vs. Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Plus, with sports betting in Missouri set to launch on December 1, 2025, Dimers has you covered with the latest news and the best pre-registration offers in MO.

Conclusion

We predict the Cubs, with a 57% win probability, will likely beat the Royals on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Royals vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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