Royals vs. Cubs Prediction: Cubs Predicted to Win Tuesday's MLB Matchup [7/22/2025]

MLB action continues on Tuesday at 8:05PM ET as the Kansas City Royals face off with the favored Chicago Cubs at Wrigley Field.

The Cubs will have Matthew Boyd (10-3, 2.34 ERA) as their starting pitcher, while the Royals will counter with Rich Hill (0-0, 0.00 ERA).

Based on the latest simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Cubs as the most likely winner of today's game.

For a closer look at Tuesday's matchup, including best bets and picks, visit our interactive Royals vs. Cubs predictions page.

Cubs vs. Royals Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data analysis, we have simulated the outcome of Tuesday's MLB game between the Royals and Cubs 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Cubs a 66% chance of defeating the Royals.

According to our model, the Royals (+1.5) have a 51% chance of covering the run line, while the over/under total of 9 runs has a 54% chance of staying under.

Royals vs. Cubs Odds [7/22/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Royals	Cubs
Run Line	+1.5 (+106)	-1.5 (-120)
Moneyline	+213	-250
Total	o9 (-102)	u9 (-118)

All odds are correct at the time of publication and are subject to change.

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Royals vs. Cubs Picks and Best Bets

Our model's strongest edge in today's Royals vs. Cubs matchup is on the total.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Royals vs. Cubs Game-Day Updates and Essential Details

Tuesday's MLB action between the Cubs and Royals at Wrigley Field is scheduled to commence at 8:05PM ET.

• Who: Kansas City Royals vs. Chicago Cubs
• Date: Tuesday, July 22, 2025
• Time: 8:05PM ET/5:05PM PT
• Venue: Wrigley Field

Dimers.com's in-depth preview of Tuesday's Royals vs. Cubs matchup includes our prediction, picks and the latest betting odds.

Before making any Royals vs. Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Cubs, with a 66% win probability, will likely beat the Royals on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Royals vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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