Royals vs. Cubs Prediction: Cubs Predicted to Win Monday's MLB Matchup [7/21/2025]

The Chicago Cubs will face the Kansas City Royals in MLB action at Wrigley Field on Monday, starting at 8:05PM ET.

Ryan Brasier (0-0, 1.04 ERA) will be on the bump for the Cubs, up against Noah Cameron (3-4, 2.31 ERA) for the Royals.

Based on the latest simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Cubs as the most likely winner of today's game.

For a closer look at Monday's matchup, including best bets and picks, visit our interactive Royals vs. Cubs predictions page.

Cubs vs. Royals Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data, we have simulated the result of Monday's MLB matchup between the Royals and Cubs 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Cubs a 56% chance of beating the Royals.

According to our model, the Royals (+1.5) have a 62% chance of covering the run line, while the over/under total of 7.5 runs has an equal 50-50 chance of hitting.

Royals vs. Cubs Odds [7/21/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Royals	Cubs
Run Line	+1.5 (-170)	-1.5 (+146)
Moneyline	+125	-144
Total	o7.5 (+100)	u7.5 (-118)

All odds are correct at the time of publication and are subject to change.

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Royals vs. Cubs Picks and Best Bets

Our model's biggest edge in today's Royals vs. Cubs matchup is on the run line.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Royals vs. Cubs Game-Day Updates and Essential Details

Monday's MLB action between the Cubs and Royals at Wrigley Field is scheduled to begin at 8:05PM ET.

• Who: Kansas City Royals vs. Chicago Cubs
• Date: Monday, July 21, 2025
• Time: 8:05PM ET/5:05PM PT
• Venue: Wrigley Field

Dimers.com's comprehensive preview of Monday's Royals vs. Cubs matchup includes our prediction, picks and the latest betting odds.

Before making any Royals vs. Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Cubs, with a 56% win probability, will likely beat the Royals on Monday.

AI and automation have enhanced this article to quickly deliver accurate Royals vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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