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Chiefs vs. Giants prediction: Kansas City favored to win SNF Week 3, 2025

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Written by Mac Douglass

Get Kansas City Chiefs vs New York Giants predictions for NFL Sunday.

Kansas City Chiefs-New York Giants Predictions and Game Preview.
Kansas City Chiefs vs. New York Giants NFL prediction for Sunday, September 21, 2025.

The New York Giants will take on the favored Kansas City Chiefs in NFL Week 3 action at MetLife Stadium on Sunday, starting at 8:20PM ET.

Based on the latest simulations, Dimers' proven NFL model projects the Chiefs as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Chiefs-Giants game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Chiefs with a win probability of 67%, while the Giants have 33%."

This gameday Chiefs vs. Giants betting preview builds on my Chiefs vs. Giants prediction that was released earlier in the week.

For expanded analysis of today’s game, including the predicted score, best bets and player prop picks, visit our interactive Chiefs vs. Giants predictions page.

Chiefs vs. Giants Predictions

Since our Chiefs-Giants predictions earlier in the week, we have simulated the outcome of Sunday's NFL game between the Chiefs and Giants 10,000 times as part of our NFL predictions coverage.

Our famous predictive model currently gives the Chiefs a 67% chance of beating the Giants in Week 3 of the NFL season. Our predicted final score has the Chiefs winning 24-19.

According to our model, the Giants (+6) have a 56% chance of covering the spread, while the 44.5-point over/under has an equal 50-50 chance of hitting.

 

Chiefs vs. Giants odds

We have sourced the best NFL odds in America for this game, which are listed here:

Bet Type Chiefs Giants
Spread -6 (-110) +6 (-105)
Moneyline -300 +260
Total o44.5 (-110) u44.5 (-105)

All odds are correct at the time of publication and are subject to change.

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Chiefs vs. Giants picks and best bets

Our model's biggest edge in today's Chiefs vs. Giants matchup is on the moneyline.

Our expert predictions, matched against the latest odds, reveal the best NFL picks and NFL best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Chiefs vs. Giants TD scorers

Who will score an anytime touchdown in Chiefs vs. Giants?

According to our model, New York's Malik Nabers is most likely to score the first touchdown in Chiefs vs. Giants.

Our projections give Nabers a 9.3% chance of getting in for six first at MetLife Stadium, while the Giants wide receiver is a 40.3% chance of scoring an anytime touchdown.

First touchdown scorer predictions

Kansas City Chiefs

Player First TD Probability
Hollywood Brown (WR) 8.2%
Travis Kelce (TE) 8.0%
Kareem Hunt (RB) 7.7%

New York Giants

Player First TD Probability
Malik Nabers (WR) 9.3%
Cam Skattebo (RB) 7.9%
Wan'Dale Robinson (WR) 5.8%

Anytime touchdown scorer predictions

Kansas City Chiefs

Player Anytime TD Probability
Hollywood Brown (WR) 33.8%
Travis Kelce (TE) 33.3%
Kareem Hunt (RB) 32.2%

New York Giants

Player Anytime TD Probability
Malik Nabers (WR) 40.3%
Cam Skattebo (RB) 35.4%
Wan'Dale Robinson (WR) 27.3%

Chiefs vs Giants player props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Chiefs and Giants. For detailed projections, join Dimers Pro.

Already a Dimers Pro member? Head to our Chiefs-Giants page now to access every player prop projection.

Chiefs vs. Giants quarterbacks

Of the starting quarterbacks, the Chiefs' Patrick Mahomes is projected to throw for more yards than the Giants' Russell Wilson.

Chiefs rushing

Isiah Pacheco, Kareem Hunt and Patrick Mahomes are projected to be the leading rushers for the Chiefs.

Player Position
Isiah Pacheco RB
Kareem Hunt RB
Patrick Mahomes QB

Giants rushing

Cam Skattebo, Tyrone Tracy and Russell Wilson are expected to lead the Giants in rushing yards.

Player Position
Cam Skattebo RB
Tyrone Tracy RB
Russell Wilson QB

Chiefs receiving

Hollywood Brown, Travis Kelce, JuJu Smith-Schuster, Tyquan Thornton and Noah Gray are projected to top the receiving yards for the Chiefs.

Player Position
Hollywood Brown WR
Travis Kelce TE
JuJu Smith-Schuster WR
Tyquan Thornton WR
Noah Gray TE

Giants receiving

Malik Nabers, Wan'Dale Robinson, Darius Slayton, Theo Johnson and Tyrone Tracy are projected to lead the Giants in receiving yards.

Player Position
Malik Nabers WR
Wan'Dale Robinson WR
Darius Slayton WR
Theo Johnson TE
Tyrone Tracy RB

Chiefs vs. Giants game-day updates and essential details

The NFL Week 3 action between the Giants and Chiefs at MetLife Stadium is scheduled to commence at 8:20PM ET.

Dimers' comprehensive preview of Sunday's Chiefs vs. Giants matchup includes our prediction, picks and the latest betting odds.

Before making any Chiefs vs. Giants picks, be sure to check out the latest NFL predictions and betting advice from Dimers Pro.

Plus, with Missouri sports betting set to launch on December 1, 2025, Dimers has everything you need—from the latest news and the best pre-registration offers in MO.

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Conclusion

We predict the Chiefs, with a 67% win probability, will likely beat the Giants in Week 3 of the NFL season.

AI and automation have enhanced this article to quickly deliver accurate Chiefs vs. Giants insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on NFL

Keep up with the latest NFL betting news and NFL parlay picks throughout the season. Plus, our Super Bowl odds offer the latest probabilities for the Super Bowl, AFC, NFC and each division.

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Written by
Mac Douglass
Senior Editor

Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.

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