Kansas City Chiefs vs. New York Giants early prediction: Expert picks for NFL Week 3, 2025

The Kansas City Chiefs and New York Giants will meet in Week 3 of the NFL season at MetLife Stadium on Sunday, September 21, 2025, starting at 8:20PM ET.

Initial simulations from Dimers' trusted NFL model favor the Chiefs as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Chiefs vs. Giants predictions page.

Kansas City vs. NY Giants early predictions

Leveraging trusted machine learning and analysis, we have simulated the Chiefs vs. Giants game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Chiefs 71%, Giants 29%
• Predicted final score: Chiefs 24-19 Giants
• Spread: Chiefs (-6.5) 43%, Giants (+6.5) 57%
• Total points (43.5): Over 50%, Under 50%

As of September 14, 2025, these Chiefs-Giants figures and predictions reflect the latest data and insights available.

Chiefs vs. Giants Week 3 details

The NFL Week 3 matchup between the Giants and Chiefs at MetLife Stadium is scheduled for September 21, 2025.

• Who: Kansas City Chiefs vs. New York Giants
• Date: Sunday, September 21, 2025
• Time: 8:20PM ET/5:20PM PT
• Venue: MetLife Stadium

Chiefs vs. Giants opening odds

We've researched the best betting odds across America for this Week 3 game, which are listed here:

• Spread: Chiefs -6.5 (-110), Giants +6.5 (-110)
• Moneyline: Chiefs -290, Giants +235
• Total: Over/Under 43.5 (-110/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Chiefs, with a 71% win probability, will likely beat the Giants in Week 3 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Chiefs vs. Giants matchup, with human oversight maintaining high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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