Kansas City Chiefs vs. Los Angeles Chargers updated prediction featuring Xavier Worthy, Omarion Hampton [Week 1, 2025]

Dimers' latest NFL predictions are live for Los Angeles Chargers and Kansas City Chiefs in Week 1, with our model giving the Chiefs a 60% of winning against the Chargers on Friday.

This update builds on our early Chargers-Chiefs predictions, producing fresh win probabilities, score projections, and TD predictions for Xavier Worthy, Omarion Hampton, and more.

For the most accurate simulation-based insights—including spread and total picks, touchdown probabilities, and the full list of player props—head to our Chiefs vs. Chargers page.

What's changed? Kansas City vs. LA Chargers updated predictions

Our NFL predictions model has been re-run with the newest available data, creating a clearer picture of how this Chiefs vs. Chargers matchup stacks up. Here are the updated forecasted:

• Straight Up Win Probabilities: Chiefs 60%, Chargers 40%
• Predicted Final Score: Chiefs 23-21 Chargers
• Spread: Chiefs (-3.5) 44%, Chargers (+3.5) 56%
• Total Points (45.5): Over 50%, Under 50%

As of September 3, 2025, these Chiefs-Chargers calculations reflect changes since our early-week simulation.

Anytime touchdown scorer predictions

New projections highlight the top candidates to find the end zone in Chiefs-Chargers on Friday:

Kansas City Chiefs

• Xavier Worthy: 37.8% probability
• Isiah Pacheco: 33.3% probability
• Travis Kelce: 29.9% probability

Los Angeles Chargers

• Omarion Hampton: 42.6% probability
• Ladd McConkey: 33.0% probability
• Najee Harris: 25.7% probability

Chiefs vs. Chargers latest odds

The best current odds from the top sportsbooks in the US:

• Spread: Chiefs -3.5 (-105), Chargers +3.5 (-125)
• Moneyline: Chiefs -168, Chargers +145
• Total: Over/Under 45.5 (-110/-105)

Odds are correct at time of publication and are subject to change—track live updates via our NFL odds page.

Chiefs vs. Chargers Week 1 details

The NFL Week 1 game between the Chargers and Chiefs at Corinthians Arena is scheduled for September 5, 2025.

• Who: Kansas City Chiefs vs. Los Angeles Chargers
• Date: Friday, September 5, 2025
• Time: 8:00PM ET/5:00PM PT
• Venue: Corinthians Arena

NFL Week 1 betting promos and codes

Make the most of Dimers' Chiefs vs. Chargers predictions by exploring the two exciting offers below.

DraftKings Sportsbook

Sign up for DraftKings Sportsbook! Bet $5, get $300 in Bonus Bets instantly plus over $200 off NFL Sunday Ticket.

Bet365 Sportsbook

Join Bet365 Sportsbook! Bet $5, get $200 in Bonus Bets win or lose.

Conclusion

We predict the Chiefs, with a 60% win probability, will likely beat the Chargers in Week 1 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Chiefs vs. Chargers game, with human oversight maintaining high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee.

More on NFL

Stay informed with the latest NFL news and data-driven parlay picks all season long. Plus, our Super Bowl odds for top predictions and the best available odds on the Super Bowl, AFC, NFC and each division.