Chiefs vs. Chargers prediction: Kansas City favored to win in NFL Week 1, 2025

The Los Angeles Chargers and Kansas City Chiefs will lock horns in Week 1 of the NFL season at Corinthians Arena in Brazil on Friday, with kickoff at 8:00PM ET.

Based on updated simulations, Dimers' proven NFL model predicts the Chiefs as the most likely winner of today's game.

This updated Chiefs vs. Chargers betting preview builds on my Chiefs vs. Chargers prediction that was posted earlier in the week.

For expanded analysis of today’s game, including the predicted score, best bets and player prop picks, visit our interactive Chiefs vs. Chargers predictions page.

Chiefs vs. Chargers Predictions

Since our Chiefs-Chargers predictions earlier in the week, we have simulated the result of Friday's NFL game between the Chiefs and Chargers 10,000 times as part of our NFL predictions coverage.

Our leading predictive model currently gives the Chiefs a 59% chance of beating the Chargers in Week 1 of the NFL season. Our predicted final score has the Chiefs winning 24-22.

According to our model, the bookmakers have got it right, and the Chiefs and Chargers each have a 50% chance of covering the spread, while the over/under total of 47.5 points also has an equal 50-50 chance of hitting.

Chiefs vs. Chargers odds

We have researched the best NFL odds in America for this game, which are listed here:

Bet Type	Chiefs	Chargers
Spread	-3 (-105)	+3 (+100)
Moneyline	-165	+145
Total	o47.5 (-110)	u47.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Chiefs vs. Chargers picks and best bets

Our model's biggest edge in today's Chiefs vs. Chargers matchup is on the total.

Our expert predictions, matched against the latest odds, reveal the best NFL picks and NFL best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Chiefs vs. Chargers TD scorers

Who will score the first touchdown in Chiefs vs. Chargers?

According to our model, Los Angeles' Omarion Hampton is most likely to score the first TD in Chiefs vs. Chargers.

Our projections give Hampton a 10.3% chance of scoring the first TD at Corinthians Arena, while the Chargers running back is a 41.7% chance of scoring an anytime touchdown.

First touchdown scorer predictions

Kansas City Chiefs

Player	First TD Probability
Xavier Worthy (WR)	9.9%
Isiah Pacheco (RB)	8.1%
Travis Kelce (TE)	6.9%

Los Angeles Chargers

Player	First TD Probability
Omarion Hampton (RB)	10.3%
Ladd McConkey (WR)	7.6%
Najee Harris (RB)	5.4%

Anytime touchdown scorer predictions

Kansas City Chiefs

Player	Anytime TD Probability
Xavier Worthy (WR)	40.1%
Isiah Pacheco (RB)	34.3%
Travis Kelce (TE)	30.1%

Los Angeles Chargers

Player	Anytime TD Probability
Omarion Hampton (RB)	41.7%
Ladd McConkey (WR)	32.9%
Najee Harris (RB)	24.6%

Chiefs vs Chargers player props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Chiefs and Chargers. For detailed projections, join Dimers Pro.

Already a Dimers Pro member? Head to our Chiefs-Chargers page now to access every player prop projection.

Chiefs vs. Chargers quarterbacks

Of the starting quarterbacks, the Chiefs' Patrick Mahomes is projected to throw for more yards than the Chargers' Justin Herbert.

Chiefs rushing

Isiah Pacheco, Kareem Hunt and Patrick Mahomes are projected to be the leading rushers for the Chiefs.

Player	Position
Isiah Pacheco	RB
Kareem Hunt	RB
Patrick Mahomes	QB

Chargers rushing

Omarion Hampton, Najee Harris and Justin Herbert are expected to lead the Chargers in rushing yards.

Player	Position
Omarion Hampton	RB
Najee Harris	RB
Justin Herbert	QB

Chiefs receiving

Xavier Worthy, Travis Kelce, Hollywood Brown, JuJu Smith-Schuster and Noah Gray are projected to top the receiving yards for the Chiefs.

Player	Position
Xavier Worthy	WR
Travis Kelce	TE
Hollywood Brown	WR
JuJu Smith-Schuster	WR
Noah Gray	TE

Chargers receiving

Ladd McConkey, Keenan Allen, Quentin Johnston, Tyler Conklin and Will Dissly are projected to lead the Chargers in receiving yards.

Player	Position
Ladd McConkey	WR
Keenan Allen	WR
Quentin Johnston	WR
Tyler Conklin	TE
Will Dissly	TE

Chiefs vs. Chargers game-day updates and essential details

The NFL Week 1 game between the Chargers and Chiefs at Corinthians Arena is scheduled to begin at 8:00PM ET.

• Who: Kansas City Chiefs vs. Los Angeles Chargers
• Date: Friday, September 5, 2025
• Time: 8:00PM ET/5:00PM PT
• Venue: Corinthians Arena (Brazil)

Dimers.com's full preview of Friday's Chiefs vs. Chargers matchup includes our prediction, picks and the latest betting odds.

Before making any Chiefs vs. Chargers picks, be sure to check out the latest NFL predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Chiefs, with a 59% win probability, will likely beat the Chargers in Week 1 of the NFL season.

AI and automation have enhanced this article to quickly deliver accurate Chiefs vs. Chargers insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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