Kansas City Chiefs vs. Los Angeles Chargers early prediction: Expert picks for NFL Week 1, 2025

The Kansas City Chiefs and Los Angeles Chargers will meet in Week 1 of the NFL season at Corinthians Arena on Friday, September 5, 2025, starting at 8:00PM ET.

Early simulations from Dimers' trusted NFL model favor the Chiefs as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Chiefs vs. Chargers predictions page.

Kansas City vs. LA Chargers early predictions

Leveraging trusted machine learning and analysis, we have simulated the Chiefs vs. Chargers game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Chiefs 60%, Chargers 40%
• Predicted final score: Chiefs 23-21 Chargers
• Spread: Chiefs (-3.5) 44%, Chargers (+3.5) 56%
• Total points (45.5): Over 50%, Under 50%

As of August 31, 2025, these Chiefs-Chargers numbers and predictions reflect the latest data and insights available.

Chiefs vs. Chargers Week 1 details

The NFL Week 1 game between the Chargers and Chiefs at Corinthians Arena is scheduled for September 5, 2025.

• Who: Kansas City Chiefs vs. Los Angeles Chargers
• Date: Friday, September 5, 2025
• Time: 8:00PM ET/5:00PM PT
• Venue: Corinthians Arena

Chiefs vs. Chargers opening odds

We've researched the best betting odds across America for this Week 1 game, which are listed here:

• Spread: Chiefs -3.5 (-105), Chargers +3.5 (-125)
• Moneyline: Chiefs -168, Chargers +145
• Total: Over/Under 45.5 (-105/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Chiefs, with a 60% win probability, will likely beat the Chargers in Week 1 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Chiefs vs. Chargers game, with human oversight maintaining high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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