Kansas City Chiefs vs. Jacksonville Jaguars early prediction: Expert picks for NFL Week 5, 2025

The Kansas City Chiefs and Jacksonville Jaguars will meet in Week 5 of the NFL season at EverBank Stadium on Monday, October 6, 2025, starting at 8:15PM ET.

Early simulations from Dimers' trusted NFL model favor the Chiefs as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Chiefs vs. Jaguars predictions page.

Kansas City vs. Jacksonville early predictions

Leveraging trusted machine learning and analysis, we have simulated the Chiefs vs. Jaguars game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Chiefs 64%, Jaguars 36%
• Predicted final score: Chiefs 25-21 Jaguars
• Spread: Chiefs (-4.5) 46%, Jaguars (+4.5) 54%
• Total points (47.5): Over 46%, Under 54%

As of September 28, 2025, these Chiefs-Jaguars calculations and predictions reflect the latest data and insights available.

Chiefs vs. Jaguars Week 5 details

The NFL Week 5 action between the Jaguars and Chiefs at EverBank Stadium is scheduled for October 6, 2025.

• Who: Kansas City Chiefs vs. Jacksonville Jaguars
• Date: Monday, October 6, 2025
• Time: 8:15PM ET/5:15PM PT
• Venue: EverBank Stadium

Chiefs vs. Jaguars opening odds

We've researched the best betting odds across America for this Week 5 game, which are listed here:

• Spread: Chiefs -4.5 (-110), Jaguars +4.5 (-110)
• Moneyline: Chiefs -218, Jaguars +180
• Total: Over/Under 47.5 (-110/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Chiefs, with a 64% win probability, will likely beat the Jaguars in Week 5 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Chiefs vs. Jaguars game, with human oversight maintaining high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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