Jordan Thompson vs. Adrian Mannarino prediction, odds, picks for US Open 2025

Jordan Thompson will take on Adrian Mannarino in the second round of the US Open Men's Singles 2025 on Wednesday.

Based on updated simulations, Dimers' proven tennis model predicts Adrian Mannarino as the most likely winner of the match.

"We have simulated the outcome of Wednesday's Thompson-Mannarino match 10,000 times," said Dimers data analyst Greg Butyn.

"With the latest updates and numerous other variables, we estimate Adrian Mannarino's chance of winning at 62%, with Jordan Thompson at 38%."

For further insights into Wednesday's match, including best bets and picks, visit our interactive Thompson vs. Mannarino predictions page.

Thompson vs. Mannarino prediction: Who will win and advance to the Round of 32?

Using powerful machine learning and data analysis, we have simulated the outcome of Wednesday's Thompson-Mannarino men's singles match 10,000 times as part of our tennis predictions coverage.

Our leading predictive model currently gives Mannarino a 62% chance of defeating Thompson in the US Open 2025.

Additionally, Mannarino has a 58% chance of winning the first set, while the over 37.5 games has a 51% chance of hitting, according to our model.

For more insights into the growing popularity of betting on the sport, check out our comprehensive analysis of tennis' rise in the U.S. sports betting market.

Jordan Thompson vs. Adrian Mannarino odds

We have researched the most up-to-date betting odds in America for this match, which are listed here:

Bet Type	Thompson	Mannarino
Moneyline	+155	-188
First Set	+120	-152
Total Games	o37.5 (-112)	u37.5 (-118)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Thompson vs. Mannarino picks and best bets

Our model's biggest edge in today's Thompson vs. Mannarino match is on the moneyline.

Our expert predictions, aligned with the latest odds, reveal the best tennis picks and tennis best bets for every tournament throughout the year.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Thompson vs. Mannarino updates and essential details

The US Open 2025 match between Jordan Thompson and Adrian Mannarino is scheduled to commence on Wednesday at 6:20PM ET.

• Who: Jordan Thompson vs. Adrian Mannarino
• Date: Wednesday, August 27, 2025
• Approx. Time: 6:20PM ET/3:20PM PT
• Tournament: US Open Men's Singles 2025
• Round: Second round

All dates and times mentioned in this article are United States Eastern Time unless otherwise stated.

Dimers.com's comprehensive preview of Wednesday's Thompson vs. Mannarino match includes our prediction, picks and the latest betting odds.

Before making any Jordan Thompson vs. Adrian Mannarino picks, be sure to check out the latest tennis predictions and betting advice from Dimers Pro.

Key tennis betting guides and insights

• Learn how to bet on tennis and understand how tennis odds work
• Explore where sports odds come from and how they’re applied to tennis matches
• Stay informed with guides on where online sports betting is currently legal and which states could legalize next
• Improve your chances with proven sports betting strategies that apply to tennis and more

Conclusion

We predict Adrian Mannarino, with a 62% win probability, will likely beat Jordan Thompson at the US Open 2025.

AI and automation have enhanced this article to quickly deliver accurate Thompson vs. Mannarino insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on Tennis

Keep up with the latest tennis news and parlay picks throughout the year. Plus, Dimers' ATP and WTA world rankings showcase our in-house approach to accurately ranking every men's and women's player in the world.