Jannik Sinner vs. Lorenzo Musetti prediction, odds, picks for US Open 2025

Jannik Sinner and Lorenzo Musetti will lock horns in the quarterfinals of the US Open 2025 on Wednesday.

Based on the latest simulations, Dimers' proven tennis model predicts Jannik Sinner as the most likely winner of the match.

"We have simulated the outcome of Wednesday's Sinner-Musetti match 10,000 times," said Dimers data analyst Greg Butyn.

"With the latest updates and numerous other variables, we estimate Jannik Sinner's chance of winning at 96%, with Lorenzo Musetti at 4%."

For further insights into Wednesday's match, including best bets and picks, visit our interactive Sinner vs. Musetti predictions page.

Sinner vs. Musetti prediction: Who will win and advance to the semifinals?

Using powerful machine learning and data, we have simulated the outcome of Wednesday's Sinner-Musetti men's singles match 10,000 times as part of our tennis predictions coverage.

Our leading predictive model currently gives Sinner a 96% chance of winning against Musetti in the US Open 2025.

Additionally, Sinner has an 89% chance of winning the first set, while the under 30.5 games has a 57% chance of hitting, according to our model.

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Jannik Sinner vs. Lorenzo Musetti odds

We have researched the most up-to-date betting odds in America for this match, which are listed here:

Bet Type	Sinner	Musetti
Moneyline	-2000	+1600
First Set	-714	+450
Total Games	o30.5 (-105)	u30.5 (-115)

All odds are correct at the time of publication and are subject to change.

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Sinner vs. Musetti picks and best bets

Our model's strongest edge in today's Sinner vs. Musetti match is on the first set.

Our expert predictions, aligned with the best odds, reveal the best tennis picks and tennis best bets for every match throughout the year.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Sinner vs. Musetti updates and essential details

The US Open 2025 match between Jannik Sinner and Lorenzo Musetti is scheduled to commence on Wednesday at 9:00PM ET.

• Who: Jannik Sinner vs. Lorenzo Musetti
• Date: Wednesday, September 3, 2025
• Approx. Time: 9:00PM ET/6:00PM PT
• Tournament: US Open Men's Singles 2025
• Round: Quarterfinals

All dates and times mentioned in this article are United States Eastern Time unless otherwise stated.

Dimers.com's in-depth preview of Wednesday's Sinner vs. Musetti match includes our prediction, picks and the latest betting odds.

Before making any Jannik Sinner vs. Lorenzo Musetti picks, be sure to check out the latest tennis predictions and betting advice from Dimers Pro.

Key tennis betting guides and insights

• Learn how to bet on tennis and understand how tennis odds work
• Explore where sports odds come from and how they’re applied to tennis matches
• Stay informed with guides on where online sports betting is currently legal and which states could legalize next
• Improve your chances with proven sports betting strategies that apply to tennis and more

Conclusion

We predict Jannik Sinner, with a 96% win probability, will likely beat Lorenzo Musetti at the US Open 2025.

AI and automation have enhanced this article to quickly deliver accurate Sinner vs. Musetti insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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