Jannik Sinner vs. Alexei Popyrin prediction, odds, picks for US Open 2025

Jannik Sinner will take on Alexei Popyrin in the second round of the US Open Men's Singles 2025 on Thursday.

Based on updated simulations, Dimers' advanced tennis model predicts Jannik Sinner as the most likely winner of the match.

For further insights into Thursday's match, including best bets and picks, visit our interactive Sinner vs. Popyrin predictions page.

Sinner vs. Popyrin prediction: Who will win and advance to the Round of 32?

Using trusted machine learning and statistical analysis, we have simulated the outcome of Thursday's Sinner-Popyrin men's singles match 10,000 times as part of our tennis predictions coverage.

Our leading predictive model gives Sinner a 97% chance of defeating Popyrin in the US Open 2025.

Additionally, Sinner has a 91% chance of winning the first set, while the under 30.5 games has a 61% chance of hitting, according to our model.

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Jannik Sinner vs. Alexei Popyrin odds

We have researched the most up-to-date betting odds in America for this match, which are listed here:

Bet Type	Sinner	Popyrin
Moneyline	-3448	+1800
First Set	-833	+500
Total Games	o30.5 (-115)	u30.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Sinner vs. Popyrin picks and best bets

Our model's biggest edge in today's Sinner vs. Popyrin match is on the first set.

Our expert predictions, aligned with the current odds, reveal the best tennis picks and tennis best bets for every match throughout the year.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Sinner vs. Popyrin updates and essential details

The US Open 2025 match between Jannik Sinner and Alexei Popyrin is scheduled to begin on Thursday at 1:55PM ET.

• Who: Jannik Sinner vs. Alexei Popyrin
• Date: Thursday, August 28, 2025
• Approx. Time: 1:55PM ET/10:55AM PT
• Tournament: US Open Men's Singles 2025
• Round: Second round

All dates and times mentioned in this article are United States Eastern Time unless otherwise noted.

Dimers.com's full preview of Thursday's Sinner vs. Popyrin match includes our prediction, picks and the latest betting odds.

Before making any Jannik Sinner vs. Alexei Popyrin picks, be sure to check out the latest tennis predictions and betting advice from Dimers Pro.

Key tennis betting guides and insights

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• Explore where sports odds come from and how they’re applied to tennis matches
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Conclusion

We predict Jannik Sinner, with a 97% win probability, will likely beat Alexei Popyrin at the US Open 2025.

AI and automation have enhanced this article to quickly deliver accurate Sinner vs. Popyrin insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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