Jan-Lennard Struff vs. Mackenzie McDonald prediction, odds, picks for US Open 2025

Jan-Lennard Struff will square off with Mackenzie McDonald in the first round of the US Open Men's Singles 2025 on Monday.

Based on updated simulation results, Dimers' proven tennis model predicts Mackenzie McDonald as the most likely winner of the match.

For expanded analysis of Monday's match, including best bets and picks, visit our interactive Struff vs. McDonald predictions page.

Struff vs. McDonald prediction: Who will win and advance to the Second Round?

Using innovative machine learning and data analysis, we have simulated the outcome of Monday's Struff-McDonald men's singles match 10,000 times as part of our tennis predictions coverage.

Our famous predictive model gives McDonald a 51% chance of winning against Struff in the US Open 2025.

Additionally, Struff has a 51% chance of winning the first set. The simulations also show McDonald (+0.5) has a 53% chance of covering the games spread, while the over 38.5 games has a 52% chance of hitting, according to our model.

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Jan-Lennard Struff vs. Mackenzie McDonald odds

We have researched the most up-to-date betting odds in America for this match, which are listed here:

Bet Type	Struff	McDonald
Moneyline	-104	-111
First Set	-111	-111
Game Spread	+0.5 (-145)	-0.5 (-110)
Total Games	o38.5 (-112)	u38.5 (-102)

All odds are correct at the time of publication and are subject to change.

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Struff vs. McDonald picks and best bets

Our model's strongest edge in today's Struff vs. McDonald match is on the first set.

Our expert predictions, matched against the best odds, reveal the best tennis picks and tennis best bets for every match throughout the year.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Struff vs. McDonald updates and essential details

The US Open 2025 match between Jan-Lennard Struff and Mackenzie McDonald is scheduled to start on Monday at 4:00PM ET.

• Who: Jan-Lennard Struff vs. Mackenzie McDonald
• Date: Monday, August 25, 2025
• Approx. Time: 4:00PM ET/1:00PM PT
• Tournament: US Open Men's Singles 2025
• Round: First round

All dates and times in this article are United States Eastern Time unless otherwise stated.

Dimers.com's in-depth preview of Monday's Struff vs. McDonald match includes our prediction, picks and the latest betting odds.

Before making any Jan-Lennard Struff vs. Mackenzie McDonald picks, be sure to check out the latest tennis predictions and betting advice from Dimers Pro.

Key tennis betting guides and insights

• Learn how to bet on tennis and understand how tennis odds work
• Explore where sports odds come from and how they’re applied to tennis matches
• Stay informed with guides on where online sports betting is currently legal and which states could legalize next
• Improve your chances with proven sports betting strategies that apply to tennis and more

Conclusion

We predict Mackenzie McDonald, with a 51% win probability, will likely beat Jan-Lennard Struff at the US Open 2025.

AI and automation have enhanced this article to quickly deliver accurate Struff vs. McDonald insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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