Jan-Lennard Struff vs. Holger Rune prediction, odds, picks for US Open 2025

Jan-Lennard Struff and Holger Rune will meet in the second round of the US Open 2025 on Wednesday.

Based on updated simulations, Dimers' proven tennis model predicts Holger Rune as the most likely winner of the match.

"We have simulated the outcome of Wednesday's Struff-Rune match 10,000 times," said Dimers data analyst Greg Butyn.

"With the latest updates and numerous other variables, we estimate Holger Rune's chance of winning at 74%, with Jan-Lennard Struff at 26%."

For a closer look at Wednesday's match, including best bets and picks, visit our interactive Struff vs. Rune predictions page.

Struff vs. Rune prediction: Who will win and advance to the Round of 32?

Using innovative machine learning and statistical analysis, we have simulated the result of Wednesday's Struff-Rune men's singles match 10,000 times as part of our tennis predictions coverage.

Our leading predictive model currently gives Rune a 74% chance of winning against Struff in the US Open 2025.

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Jan-Lennard Struff vs. Holger Rune odds

We have researched the most up-to-date betting odds in America for this match, which are listed here:

Bet Type	Struff	Rune
Moneyline	+245	-300
Total Games	o39.5 (-105)	u39.5 (-130)

All odds are correct at the time of publication and are subject to change.

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Struff vs. Rune picks and best bets

Our model's biggest edge in today's Struff vs. Rune match is on the first set.

Our expert predictions, matched against the best odds, reveal the best tennis picks and tennis best bets for every match throughout the year.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Struff vs. Rune updates and essential details

The US Open 2025 match between Jan-Lennard Struff and Holger Rune is scheduled to start on Wednesday at 6:55PM ET.

• Who: Jan-Lennard Struff vs. Holger Rune
• Date: Wednesday, August 27, 2025
• Approx. Time: 6:55PM ET/3:55PM PT
• Tournament: US Open Men's Singles 2025
• Round: Second round

All dates and times in this article are United States Eastern Time unless otherwise stated.

Dimers.com's full preview of Wednesday's Struff vs. Rune match includes our prediction, picks and the latest betting odds.

Before making any Jan-Lennard Struff vs. Holger Rune picks, be sure to check out the latest tennis predictions and betting advice from Dimers Pro.

Key tennis betting guides and insights

• Learn how to bet on tennis and understand how tennis odds work
• Explore where sports odds come from and how they’re applied to tennis matches
• Stay informed with guides on where online sports betting is currently legal and which states could legalize next
• Improve your chances with proven sports betting strategies that apply to tennis and more

Conclusion

We predict Holger Rune, with a 74% win probability, will likely beat Jan-Lennard Struff at the US Open 2025.

AI and automation have enhanced this article to quickly deliver accurate Struff vs. Rune insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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