James Madison vs. Louisville prediction: Louisville favored to win in college football Week 2, 2025

Louisville will square off with James Madison in Week 2 college football action at L&N Federal Credit Union Stadium on Friday, with kickoff at 7:00PM ET.

Based on the latest simulation results, Dimers' advanced college football model predicts Louisville as the most likely winner of today's game.

For further insights into Friday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive James Madison vs. Louisville predictions page.

James Madison vs. Louisville prediction: Who will win, cover the spread?

Using powerful machine learning and data analysis, we have simulated the outcome of James Madison vs. Louisville 10,000 times as part of our college football predictions coverage.

Our leading predictive model gives Louisville an 83% chance of defeating James Madison. Our predicted final score has Louisville winning 34-20.

According to our model, Louisville (-12.5) has a 52% chance of covering the spread, while the over/under total of 55.5 points has a 52% chance of going over.

James Madison vs. Louisville odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	James Madison	Louisville
Spread	+12.5 (-118)	-12.5 (-112)
Moneyline	+475	-500
Total	o55.5 (-110)	u55.5 (-120)

All odds are correct at the time of publication and are subject to change.

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James Madison vs. Louisville picks and best bets

Our model's strongest edge in today's James Madison vs. Louisville matchup is on the moneyline.

Our expert predictions, aligned with the latest odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

James Madison vs. Louisville game-day updates and essential details

Friday's college football game between Louisville and James Madison at L&N Federal Credit Union Stadium is scheduled to start at 7:00PM ET.

• Who: James Madison vs. Louisville
• Date: Friday, September 5, 2025
• Time: 7:00PM ET/4:00PM PT
• Venue: L&N Federal Credit Union Stadium

Dimers.com's comprehensive preview of Friday's James Madison vs. Louisville matchup includes our prediction, picks and the latest betting odds.

Before making any James Madison vs. Louisville picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Louisville, with an 83% win probability, will likely beat James Madison on Friday.

AI and automation have enhanced this article to quickly deliver accurate James Madison vs. Louisville insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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