James Madison vs. Liberty prediction: James Madison favored to win in college football Week 4, 2025

Liberty and James Madison will meet in Week 4 college football action at Williams Stadium on Saturday, with kickoff at 3:30PM ET.

Based on updated simulation results, Dimers' advanced college football model predicts James Madison as the most likely winner of today's game.

For further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive James Madison vs. Liberty predictions page.

James Madison vs. Liberty prediction: Who will win, cover the spread?

Using trusted machine learning and data analysis, we have simulated the outcome of James Madison vs. Liberty 10,000 times as part of our college football predictions coverage.

Our famous predictive model gives James Madison a 71% chance of defeating Liberty. Our predicted final score has James Madison winning 27-20.

According to our model, the bookmakers have got it right, and James Madison and Liberty each have a 50% chance of covering the spread, while the 46.5-point over/under has a 52% chance of staying under.

James Madison vs. Liberty odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	James Madison	Liberty
Spread	-7.5 (-108)	+7.5 (-110)
Moneyline	-298	+250
Total	o46.5 (-110)	u46.5 (-105)

All odds are correct at the time of publication and are subject to change.

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James Madison vs. Liberty picks and best bets

Our model's strongest edge in today's James Madison vs. Liberty matchup is on the spread.

Our expert predictions, matched against the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

James Madison vs. Liberty game-day updates and essential details

Saturday's college football matchup between Liberty and James Madison at Williams Stadium is scheduled to commence at 3:30PM ET.

• Who: James Madison vs. Liberty
• Date: Saturday, September 20, 2025
• Time: 3:30PM ET/12:30PM PT
• Venue: Williams Stadium

Dimers' in-depth preview of Saturday's James Madison vs. Liberty matchup includes our prediction, picks and the latest betting odds.

Before making any James Madison vs. Liberty picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict James Madison, with a 71% win probability, will likely beat Liberty on Saturday.

AI and automation have enhanced this article to quickly deliver accurate James Madison vs. Liberty insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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