Jacksonville State vs. Southern Miss prediction: Southern Miss favored to win in college football Week 5, 2025

Southern Miss and Jacksonville State will lock horns in Week 5 college football action at M.M. Roberts Stadium on Saturday, beginning at 7:00PM ET.

Based on the latest simulation results, Dimers' advanced college football model predicts Southern Miss as the most likely winner of today's game.

For a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Jacksonville State vs. Southern Miss predictions page.

Jacksonville State vs. Southern Miss prediction: Who will win, cover the spread?

Using powerful machine learning and statistical analysis, we have simulated the result of Jacksonville State vs. Southern Miss 10,000 times as part of our college football predictions coverage.

Our independent predictive model currently gives Southern Miss a 58% chance of defeating Jacksonville State. Our predicted final score has Southern Miss winning 29-25.

According to our model, Jacksonville State (+4.5) has a 52% chance of covering the spread, while the 55.5-point over/under has a 52% chance of going over.

Jacksonville State vs. Southern Miss odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	Jacksonville State	Southern Miss
Spread	+4.5 (-108)	-4.5 (-110)
Moneyline	+170	-184
Total	o55.5 (-110)	u55.5 (-105)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Jacksonville State vs. Southern Miss picks and best bets

Our model's strongest edge in today's Jacksonville State vs. Southern Miss matchup is on the moneyline.

Our expert predictions, matched against the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Jacksonville State vs. Southern Miss game-day updates and essential details

Saturday's college football matchup between Southern Miss and Jacksonville State at M.M. Roberts Stadium is scheduled to begin at 7:00PM ET.

• Who: Jacksonville State vs. Southern Miss
• Date: Saturday, September 27, 2025
• Time: 7:00PM ET/4:00PM PT
• Venue: M.M. Roberts Stadium

Dimers' comprehensive preview of Saturday's Jacksonville State vs. Southern Miss matchup includes our prediction, picks and the latest betting odds.

Before making any Jacksonville State vs. Southern Miss picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

Conclusion

We predict Southern Miss, with a 58% win probability, will likely beat Jacksonville State on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Jacksonville State vs. Southern Miss insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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