Jacksonville Jaguars vs. San Francisco 49ers updated prediction featuring Travis Etienne, Christian McCaffrey [Week 4, 2025]

Dimers' latest NFL predictions are live for San Francisco 49ers and Jacksonville Jaguars in Week 4, with our model giving the 49ers a 62% of winning against the Jaguars on Sunday.

This update builds on our early 49ers-Jaguars predictions, adding renewed win probabilities, score projections, and TD predictions for Travis Etienne, Christian McCaffrey, and more.

For the most accurate simulation-based insights—including spread and total picks, touchdown probabilities, and the full list of player props—head to our Jaguars vs. 49ers page.

What's changed? Jacksonville vs. San Francisco updated predictions

Our NFL predictions model has been re-run with the newest available data, creating a clearer picture of how this Jaguars vs. Niners matchup stacks up. Here are the updated forecasted:

• Straight Up Win Probabilities: Jaguars 38%, 49ers 62%
• Predicted Final Score: Jaguars 21-24 49ers
• Spread: Jaguars (+3.5) 50%, 49ers (-3.5) 50%
• Total Points (47.5): Over 48%, Under 52%

As of September 25, 2025, these Jaguars-49ers numbers reflect changes since our early-week simulation.

Anytime touchdown scorer predictions

New projections highlight the top candidates to find the end zone in Jaguars-Niners on Sunday:

Jacksonville Jaguars

• Travis Etienne: 36.7% probability
• Brian Thomas: 32.7% probability
• Bhayshul Tuten: 27.9% probability

San Francisco 49ers

• Christian McCaffrey: 59.1% probability
• Jauan Jennings: 32.0% probability
• Ricky Pearsall: 31.5% probability

Jaguars vs. Niners latest odds

The best current odds from the top sportsbooks in the US:

• Spread: Jaguars +3.5 (-115), 49ers -3.5 (-102)
• Moneyline: Jaguars +150, 49ers -175
• Total: Over/Under 47.5 (-105/-115)

Odds are correct at time of publication and are subject to change—track live updates via our NFL odds page.

Jaguars vs. Niners Week 4 details

The NFL Week 4 matchup between the 49ers and Jaguars at Levi's Stadium is scheduled for September 28, 2025.

• Who: Jacksonville Jaguars vs. San Francisco 49ers
• Date: Sunday, September 28, 2025
• Time: 4:05PM ET/1:05PM PT
• Venue: Levi's Stadium

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Conclusion

We predict the 49ers, with a 62% win probability, will likely beat the Jaguars in Week 4 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Jaguars vs. 49ers matchup, with human oversight maintaining high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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