Jaguars vs. 49ers prediction: San Francisco favored to win in NFL Week 4, 2025

The San Francisco 49ers will take on the Jacksonville Jaguars in NFL Week 4 action at Levi's Stadium on Sunday, commencing at 4:05PM ET.

Based on the latest simulations, Dimers' advanced NFL model predicts the 49ers as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Jaguars-49ers game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the 49ers with a win probability of 62%, while the Jaguars have 38%."

This gameday Jaguars vs. 49ers betting preview builds on my Jaguars vs. 49ers prediction that was published earlier in the week.

For expanded analysis of today’s game, including the predicted score, best bets and player prop picks, visit our interactive Jaguars vs. 49ers predictions page.

Jaguars vs. 49ers Predictions

Since our Jaguars-49ers predictions earlier in the week, we have simulated the result of Sunday's NFL matchup between the Jaguars and 49ers 10,000 times as part of our NFL predictions coverage.

Our independent predictive model currently gives the 49ers a 62% chance of defeating the Jaguars in Week 4 of the NFL season. Our predicted final score has the 49ers winning 24-21.

According to our model, the bookmakers have got it right, and the Jaguars and 49ers each have a 50% chance of covering the spread, while the 45.5-point over/under also has an equal 50-50 chance of hitting.

Jaguars vs. 49ers odds

We have researched the best NFL odds in America for this game, which are listed here:

Bet Type	Jaguars	49ers
Spread	+3.5 (-120)	-3.5 (+104)
Moneyline	+150	-168
Total	o45.5 (-110)	u45.5 (-104)

All odds are correct at the time of publication and are subject to change.

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Jaguars vs. 49ers picks and best bets

Our model's strongest edge in today's Jaguars vs. 49ers matchup is on the total.

Our expert predictions, matched against the latest odds, reveal the best NFL picks and NFL best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Jaguars vs. 49ers TD scorers

Who will score an anytime touchdown in Jaguars vs. 49ers?

According to our model, San Francisco's Christian McCaffrey is most likely to score the first touchdown in Jaguars vs. 49ers.

Our projections give McCaffrey a 16.8% chance of getting in for six first at Levi's Stadium, while the 49ers running back is a 58.6% chance of scoring an anytime touchdown.

First touchdown scorer predictions

Jacksonville Jaguars

Player	First TD Probability
Travis Etienne (RB)	8.7%
Brian Thomas (WR)	8.1%
Bhayshul Tuten (RB)	5.4%

San Francisco 49ers

Player	First TD Probability
Christian McCaffrey (RB)	16.8%
Ricky Pearsall (WR)	7.2%
Jauan Jennings (WR)	6.7%

Anytime touchdown scorer predictions

Jacksonville Jaguars

Player	Anytime TD Probability
Travis Etienne (RB)	35.5%
Brian Thomas (WR)	33.7%
Bhayshul Tuten (RB)	23.9%

San Francisco 49ers

Player	Anytime TD Probability
Christian McCaffrey (RB)	58.6%
Ricky Pearsall (WR)	31.4%
Jauan Jennings (WR)	29.7%

Jaguars vs 49ers player props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Jaguars and 49ers. For detailed projections, join Dimers Pro.

Already a Dimers Pro member? Head to our Jaguars-49ers page now to access every player prop projection.

Jaguars vs. 49ers quarterbacks

Of the starting quarterbacks, the Jaguars' Trevor Lawrence is projected to throw for fewer yards than the 49ers' Brock Purdy.

Jaguars rushing

Travis Etienne, Bhayshul Tuten and Trevor Lawrence are projected to be the leading rushers for the Jaguars.

Player	Position
Travis Etienne	RB
Bhayshul Tuten	RB
Trevor Lawrence	QB

49ers rushing

Christian McCaffrey, Brian Robinson and Brock Purdy are expected to lead the 49ers in rushing yards.

Player	Position
Christian McCaffrey	RB
Brian Robinson	RB
Brock Purdy	QB

Jaguars receiving

Brian Thomas, Parker Washington, Travis Hunter, Brenton Strange and Travis Etienne are projected to top the receiving yards for the Jaguars.

Player	Position
Brian Thomas	WR
Parker Washington	WR
Travis Hunter	WR
Brenton Strange	TE
Travis Etienne	RB

49ers receiving

Ricky Pearsall, Jauan Jennings, Christian McCaffrey, Jake Tonges and Kendrick Bourne are projected to lead the 49ers in receiving yards.

Player	Position
Ricky Pearsall	WR
Jauan Jennings	WR
Christian McCaffrey	RB
Jake Tonges	TE
Kendrick Bourne	WR

Jaguars vs. Niners game-day updates and essential details

The NFL Week 4 matchup between the 49ers and Jaguars at Levi's Stadium is scheduled to start at 4:05PM ET.

• Who: Jacksonville Jaguars vs. San Francisco 49ers
• Date: Sunday, September 28, 2025
• Time: 4:05PM ET/1:05PM PT
• Venue: Levi's Stadium

Dimers' in-depth preview of Sunday's Jaguars vs. 49ers matchup includes our prediction, picks and the latest betting odds.

Before making any Jaguars vs. Niners picks, be sure to check out the latest NFL predictions and betting advice from Dimers Pro.

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Conclusion

We predict the 49ers, with a 62% win probability, will likely beat the Jaguars in Week 4 of the NFL season.

AI and automation have enhanced this article to quickly deliver accurate Jaguars vs. 49ers insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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