Jacksonville Jaguars vs. Cincinnati Bengals early prediction: Expert picks for NFL Week 2, 2025

The Jacksonville Jaguars and Cincinnati Bengals will meet in Week 2 of the NFL season at Paycor Stadium on Sunday, September 14, 2025, starting at 1:00PM ET.

Initial simulations from Dimers' trusted NFL model favor the Bengals as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Jaguars vs. Bengals predictions page.

Jacksonville vs. Cincinnati early predictions

Leveraging trusted machine learning and analysis, we have simulated the Jaguars vs. Bengals game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Jaguars 32%, Bengals 68%
• Predicted final score: Jaguars 22-27 Bengals
• Spread: Jaguars (+5.5) 50%, Bengals (-5.5) 50%
• Total points (49.5): Over 50%, Under 50%

As of September 7, 2025, these Jaguars-Bengals figures and predictions reflect the latest data and insights available.

Jaguars vs. Bengals Week 2 details

The NFL Week 2 game between the Bengals and Jaguars at Paycor Stadium is scheduled for September 14, 2025.

• Who: Jacksonville Jaguars vs. Cincinnati Bengals
• Date: Sunday, September 14, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Paycor Stadium

Jaguars vs. Bengals opening odds

We've researched the best betting odds across America for this Week 2 game, which are listed here:

• Spread: Jaguars +5.5 (-110), Bengals -5.5 (-110)
• Moneyline: Jaguars +195, Bengals -238
• Total: Over/Under 49.5 (-110/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Bengals, with a 68% win probability, will likely beat the Jaguars in Week 2 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Jaguars vs. Bengals game, with human oversight maintaining high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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