Jackson State vs. Southern University prediction: Jackson State favored to win in college football Week 5, 2025

Southern University and Jackson State will clash in Week 5 college football action at A.W. Mumford Stadium on Saturday, starting at 7:00PM ET.

Based on the latest simulations, Dimers' advanced college football model predicts Jackson State as the most likely winner of today's game.

For a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Jackson State vs. Southern University predictions page.

Jackson State vs. Southern University prediction: Who will win, cover the spread?

Using powerful machine learning and statistical analysis, we have simulated the result of Jackson State vs. Southern University 10,000 times as part of our college football predictions coverage.

Our leading predictive model currently gives Jackson State a 76% chance of defeating Southern University. Our predicted final score has Jackson State winning 30-20.

According to our model, Southern University (+11.5) has a 52% chance of covering the spread, while the over/under total of 50.5 points has a 52% chance of going over.

Jackson State vs. Southern University odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	Jackson State	Southern University
Spread	-11.5 (-108)	+11.5 (-112)
Moneyline	-400	+350
Total	o50.5 (-110)	u50.5 (-110)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Jackson State vs. Southern University picks and best bets

Our model's biggest edge in today's Jackson State vs. Southern University matchup is on the moneyline.

Our expert predictions, matched against the best odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Jackson State vs. Southern University game-day updates and essential details

Saturday's college football game between Southern University and Jackson State at A.W. Mumford Stadium is scheduled to commence at 7:00PM ET.

• Who: Jackson State vs. Southern University
• Date: Saturday, September 27, 2025
• Time: 7:00PM ET/4:00PM PT
• Venue: A.W. Mumford Stadium

Dimers' full preview of Saturday's Jackson State vs. Southern University matchup includes our prediction, picks and the latest betting odds.

Before making any Jackson State vs. Southern University picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

Conclusion

We predict Jackson State, with a 76% win probability, will likely beat Southern University on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Jackson State vs. Southern University insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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