Iowa vs. Iowa State prediction: Why Iowa State is favored to win in college football Week 2, 2025

Iowa State and Iowa will meet in Week 2 college football action at Jack Trice Stadium on Saturday, commencing at 12:00PM ET.

Based on the latest simulation results, Dimers' advanced college football model projects Iowa State as the most likely winner of today's game.

For further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Iowa vs. Iowa State predictions page.

Iowa vs. Iowa State prediction: Who will win, cover the spread?

Using trusted machine learning and data, we have simulated the outcome of Iowa vs. Iowa State 10,000 times as part of our college football predictions coverage.

Our leading predictive model currently gives Iowa State a 65% chance of defeating Iowa. Our predicted final score has Iowa State winning 25-20.

According to our model, Iowa State (-3) has a 56% chance of covering the spread, while the over/under total of 42.5 points has a 59% chance of staying under.

Iowa vs. Iowa State odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Iowa	Iowa State
Spread	+3 (-105)	-3 (-115)
Moneyline	+180	-165
Total	o42.5 (-110)	u42.5 (-105)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Iowa vs. Iowa State picks and best bets

Our model's strongest edge in today's Iowa vs. Iowa State matchup is on the spread.

Our expert predictions, aligned with the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Iowa vs. Iowa State game-day updates and essential details

Saturday's college football matchup between Iowa State and Iowa at Jack Trice Stadium is scheduled to begin at 12:00PM ET.

• Who: Iowa vs. Iowa State
• Date: Saturday, September 6, 2025
• Time: 12:00PM ET/9:00AM PT
• Venue: Jack Trice Stadium

Dimers.com's comprehensive preview of Saturday's Iowa vs. Iowa State matchup includes our prediction, picks and the latest betting odds.

Before making any Iowa vs. Iowa State picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

Sports betting deal available for NCAAF Saturday

To make the most of Saturday's enormous day of sports, headlined by clashes like this one for college football Saturday, check out details on the latest Bet365 bonus code "DIMERS" that grants you $300 in bonus bets from a $5 bet — win or lose. Don't miss out!

Conclusion

We predict Iowa State, with a 65% win probability, will likely beat Iowa on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Iowa vs. Iowa State insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on College Football

Keep up with the latest college football betting news and CFB parlay picks throughout the season. Plus, our College Football National Championship odds offer the latest probabilities for the national title game and major conferences.