Iowa State vs. Arkansas State prediction: Why Iowa State is favored to win in college football Week 3, 2025

Arkansas State will face the favored Iowa State in Week 3 college football action at Centennial Bank Stadium on Saturday, beginning at 4:00PM ET.

Based on the latest simulations, Dimers' proven college football model predicts Iowa State as the most likely winner of today's game.

For further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Iowa State vs. Arkansas State predictions page.

Iowa State vs. Arkansas State prediction: Who will win, cover the spread?

Using innovative machine learning and data analysis, we have simulated the result of Iowa State vs. Arkansas State 10,000 times as part of our college football predictions coverage.

Our leading predictive model currently gives Iowa State a 90% chance of defeating Arkansas State. Our predicted final score has Iowa State winning 38-17.

According to our model, Arkansas State (+21.5) has a 53% chance of covering the spread, while the 55.5-point over/under has an equal 50-50 chance of hitting.

Iowa State vs. Arkansas State odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	Iowa State	Arkansas State
Spread	-21.5 (-102)	+21.5 (-110)
Moneyline	-1450	+980
Total	o55.5 (-115)	u55.5 (-105)

All odds are correct at the time of publication and are subject to change.

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Iowa State vs. Arkansas State picks and best bets

Our model's biggest edge in today's Iowa State vs. Arkansas State matchup is on the moneyline.

Our expert predictions, aligned with the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Iowa State vs. Arkansas State game-day updates and essential details

Saturday's college football action between Arkansas State and Iowa State at Centennial Bank Stadium is scheduled to start at 4:00PM ET.

• Who: Iowa State vs. Arkansas State
• Date: Saturday, September 13, 2025
• Time: 4:00PM ET/1:00PM PT
• Venue: Centennial Bank Stadium

Dimers' comprehensive preview of Saturday's Iowa State vs. Arkansas State matchup includes our prediction, picks and the latest betting odds.

Before making any Iowa State vs. Arkansas State picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Iowa State, with a 90% win probability, will likely beat Arkansas State on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Iowa State vs. Arkansas State insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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