Indianapolis Colts vs. Tennessee Titans updated prediction featuring Jonathan Taylor, Tony Pollard [Week 3, 2025]

Dimers' latest NFL predictions are live for Tennessee Titans and Indianapolis Colts in Week 3, with our model giving the Colts a 67% of winning against the Titans on Sunday.

This update builds on our early Titans-Colts predictions, adding updated win probabilities, score projections, and TD predictions for Jonathan Taylor, Tony Pollard, and more.

For the most accurate simulation-based insights—including spread and total picks, touchdown probabilities, and the full list of player props—head to our Colts vs. Titans page.

What's changed? Indianapolis vs. Tennessee updated predictions

Our NFL predictions model has been re-run with the newest available data, creating a clearer picture of how this Colts vs. Titans matchup stacks up. Here are the updated forecasted:

• Straight Up Win Probabilities: Colts 67%, Titans 33%
• Predicted Final Score: Colts 24-19 Titans
• Spread: Colts (-3.5) 54%, Titans (+3.5) 46%
• Total Points (43.5): Over 50%, Under 50%

As of September 18, 2025, these Colts-Titans figures reflect changes since our early-week simulation.

Anytime touchdown scorer predictions

New projections highlight the top candidates to find the end zone in Colts-Titans on Sunday:

Indianapolis Colts

• Jonathan Taylor: 56.1% probability
• Daniel Jones: 29.1% probability
• Tyler Warren: 26.1% probability

Tennessee Titans

• Tony Pollard: 42.5% probability
• Calvin Ridley: 27.3% probability
• Elic Ayomanor: 24.3% probability

Colts vs. Titans latest odds

The best current odds from the top sportsbooks in the US:

• Spread: Colts -3.5 (-115), Titans +3.5 (-105)
• Moneyline: Colts -198, Titans +176
• Total: Over/Under 43.5 (-106/-110)

Odds are correct at time of publication and are subject to change—track live updates via our NFL odds page.

Colts vs. Titans Week 3 details

The NFL Week 3 game between the Titans and Colts at Nissan Stadium is scheduled for September 21, 2025.

• Who: Indianapolis Colts vs. Tennessee Titans
• Date: Sunday, September 21, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Nissan Stadium

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Conclusion

We predict the Colts, with a 67% win probability, will likely beat the Titans in Week 3 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Colts vs. Titans game, with human oversight maintaining high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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