Colts vs. Titans prediction: Why Indianapolis is favored to win in NFL Week 3, 2025

The Tennessee Titans will face the favored Indianapolis Colts in NFL Week 3 action at Nissan Stadium on Sunday, beginning at 1:00PM ET.

Based on updated simulations, Dimers' advanced NFL model predicts the Colts as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Colts-Titans game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Colts with a win probability of 70%, while the Titans have 30%."

This gameday Colts vs. Titans betting preview builds on my Colts vs. Titans prediction that was released earlier in the week.

For further insights into today’s game, including the predicted score, best bets and player prop picks, visit our interactive Colts vs. Titans predictions page.

Colts vs. Titans Predictions

Since our Colts-Titans predictions earlier in the week, we have simulated the outcome of Sunday's NFL matchup between the Colts and Titans 10,000 times as part of our NFL predictions coverage.

Our famous predictive model gives the Colts a 70% chance of defeating the Titans in Week 3 of the NFL season. Our predicted final score has the Colts winning 24-19.

According to our model, the Titans (+6) have a 51% chance of covering the spread, while the 42.5-point over/under has a 52% chance of going over.

Colts vs. Titans odds

We have researched the best NFL odds in America for this game, which are listed here:

Bet Type	Colts	Titans
Spread	-6 (-108)	+6 (-110)
Moneyline	-250	+225
Total	o42.5 (-108)	u42.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Colts vs. Titans picks and best bets

Our model's biggest edge in today's Colts vs. Titans matchup is on the spread.

Our expert predictions, matched against the best odds, reveal the best NFL picks and NFL best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Colts vs. Titans TD scorers

Who will score an anytime touchdown in Colts vs. Titans?

According to our model, Indianapolis' Jonathan Taylor is most likely to score the first touchdown in Colts vs. Titans.

Our projections give Taylor a 17.5% chance of scoring the first TD at Nissan Stadium, while the Colts running back is a 57.4% chance of scoring an anytime touchdown.

First touchdown scorer predictions

Indianapolis Colts

Player	First TD Probability
Jonathan Taylor (RB)	17.5%
Daniel Jones (QB)	7.1%
Tyler Warren (TE)	5.8%

Tennessee Titans

Player	First TD Probability
Tony Pollard (RB)	11.5%
Calvin Ridley (WR)	7.2%
Elic Ayomanor (WR)	5.7%

Anytime touchdown scorer predictions

Indianapolis Colts

Player	Anytime TD Probability
Jonathan Taylor (RB)	57.4%
Daniel Jones (QB)	29.2%
Tyler Warren (TE)	24.5%

Tennessee Titans

Player	Anytime TD Probability
Tony Pollard (RB)	40.6%
Calvin Ridley (WR)	27.8%
Elic Ayomanor (WR)	22.6%

Colts vs Titans player props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Colts and Titans. For detailed projections, join Dimers Pro.

Already a Dimers Pro member? Head to our Colts-Titans page now to access every player prop projection.

Colts vs. Titans quarterbacks

Of the starting quarterbacks, the Colts' Daniel Jones is projected to throw for more yards than the Titans' Cam Ward.

Colts rushing

Jonathan Taylor, Daniel Jones and DJ Giddens are projected to be the leading rushers for the Colts.

Player	Position
Jonathan Taylor	RB
Daniel Jones	QB
DJ Giddens	RB

Titans rushing

Tony Pollard, Julius Chestnut and Cam Ward are expected to lead the Titans in rushing yards.

Player	Position
Tony Pollard	RB
Julius Chestnut	RB
Cam Ward	QB

Colts receiving

Michael Pittman, Tyler Warren, Josh Downs, Alec Pierce and Jonathan Taylor are projected to top the receiving yards for the Colts.

Player	Position
Michael Pittman	WR
Tyler Warren	TE
Josh Downs	WR
Alec Pierce	WR
Jonathan Taylor	RB

Titans receiving

Calvin Ridley, Elic Ayomanor, Chig Okonkwo, Tyler Lockett and Chimere Dike are projected to lead the Titans in receiving yards.

Player	Position
Calvin Ridley	WR
Elic Ayomanor	WR
Chig Okonkwo	TE
Tyler Lockett	WR
Chimere Dike	WR

Colts vs. Titans game-day updates and essential details

The NFL Week 3 matchup between the Titans and Colts at Nissan Stadium is scheduled to commence at 1:00PM ET.

• Who: Indianapolis Colts vs. Tennessee Titans
• Date: Sunday, September 21, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Nissan Stadium

Dimers' in-depth preview of Sunday's Colts vs. Titans matchup includes our prediction, picks and the latest betting odds.

Before making any Colts vs. Titans picks, be sure to check out the latest NFL predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Colts, with a 70% win probability, will likely beat the Titans in Week 3 of the NFL season.

AI and automation have enhanced this article to quickly deliver accurate Colts vs. Titans insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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