Indianapolis Colts vs. Tennessee Titans early prediction: Expert picks for NFL Week 3, 2025

The Indianapolis Colts and Tennessee Titans will meet in Week 3 of the NFL season at Nissan Stadium on Sunday, September 21, 2025, starting at 1:00PM ET.

Initial simulations from Dimers' trusted NFL model favor the Titans as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Colts vs. Titans predictions page.

Indianapolis vs. Tennessee early predictions

Leveraging trusted machine learning and analysis, we have simulated the Colts vs. Titans game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Colts 45%, Titans 55%
• Predicted final score: Colts 21-23 Titans
• Spread: Colts (+1.5) 50%, Titans (-1.5) 50%
• Total points (45.5): Over 45%, Under 55%

As of September 14, 2025, these Colts-Titans numbers and predictions reflect the latest data and insights available.

Colts vs. Titans Week 3 details

The NFL Week 3 action between the Titans and Colts at Nissan Stadium is scheduled for September 21, 2025.

• Who: Indianapolis Colts vs. Tennessee Titans
• Date: Sunday, September 21, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Nissan Stadium

Colts vs. Titans opening odds

We've researched the best betting odds across America for this Week 3 game, which are listed here:

• Spread: Colts +1.5 (-110), Titans -1.5 (-110)
• Moneyline: Colts +105, Titans -120
• Total: Over/Under 45.5 (-105/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Titans, with a 55% win probability, will likely beat the Colts in Week 3 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Colts vs. Titans matchup, with human oversight maintaining high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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