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Indianapolis Colts vs. Los Angeles Rams updated prediction featuring Jonathan Taylor, Kyren Williams [Week 4, 2025]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Get new expert Colts vs Rams predictions for Sunday's game.
Dimers' latest NFL predictions are live for Los Angeles Rams and Indianapolis Colts in Week 4, with our model giving the Rams a 60% of winning against the Colts on Sunday.
This update builds on our early Rams-Colts predictions, generating updated win probabilities, score projections, and TD predictions for Jonathan Taylor, Kyren Williams, and more.
For the most accurate simulation-based insights—including spread and total picks, touchdown probabilities, and the full list of player props—head to our Colts vs. Rams page.
What's changed? Indianapolis vs. LA Rams updated predictions
Our NFL predictions model has been re-run with the newest available data, creating a clearer picture of how this Colts vs. Rams matchup stacks up. Here are the updated forecasted:
- Straight Up Win Probabilities: Colts 40%, Rams 60%
- Predicted Final Score: Colts 23-26 Rams
- Spread: Colts (+3.5) 59%, Rams (-3.5) 41%
- Total Points (49.5): Over 50%, Under 50%
As of September 25, 2025, these Colts-Rams calculations reflect changes since our early-week simulation.
Anytime touchdown scorer predictions
New projections highlight the top candidates to find the end zone in Colts-Rams on Sunday:
Indianapolis Colts
- Jonathan Taylor: 58.2% probability
- Daniel Jones: 31.5% probability
- Tyler Warren: 28.1% probability
Los Angeles Rams
- Kyren Williams: 57.7% probability
- Puka Nacua: 39.9% probability
- Davante Adams: 39.9% probability
Colts vs. Rams latest odds
The best current odds from the top sportsbooks in the US:
- Spread: Colts +3.5 (-105), Rams -3.5 (-105)
- Moneyline: Colts +160, Rams -178
- Total: Over/Under 49.5 (-108/-105)
Odds are correct at time of publication and are subject to change—track live updates via our NFL odds page.
Colts vs. Rams Week 4 details
The NFL Week 4 action between the Rams and Colts at SoFi Stadium is scheduled for September 28, 2025.
- Who: Indianapolis Colts vs. Los Angeles Rams
- Date: Sunday, September 28, 2025
- Time: 4:05PM ET/1:05PM PT
- Venue: SoFi Stadium
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Conclusion
We predict the Rams, with a 60% win probability, will likely beat the Colts in Week 4 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.
Enhanced by AI and automation, this article delivers quick, accurate insights on the Colts vs. Rams matchup, with human oversight maintaining high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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More on NFL
Stay up-to-date with the latest NFL betting news and data-led parlay picks all season long. Plus, our Super Bowl odds for top predictions and the best available odds on the Super Bowl, AFC, NFC and each division.
Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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