Colts vs. Rams prediction: Rams favored to win in NFL Week 4, 2025

The Los Angeles Rams will face the Indianapolis Colts in NFL Week 4 action at SoFi Stadium on Sunday, beginning at 4:05PM ET.

Based on the latest simulations, Dimers' proven NFL model projects the Rams as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Colts-Rams game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Rams with a win probability of 60%, while the Colts have 40%."

This gameday Colts vs. Rams betting preview builds on my Colts vs. Rams prediction that was released earlier in the week.

For a closer look at today’s game, including the predicted score, best bets and player prop picks, visit our interactive Colts vs. Rams predictions page.

Colts vs. Rams Predictions

Since our Colts-Rams predictions earlier in the week, we have simulated the outcome of Sunday's NFL matchup between the Colts and Rams 10,000 times as part of our NFL predictions coverage.

Our independent predictive model currently gives the Rams a 60% chance of defeating the Colts in Week 4 of the NFL season. Our predicted final score has the Rams winning 26-23.

According to our model, the Colts (+3.5) have a 59% chance of covering the spread, while the over/under total of 49.5 points has an equal 50-50 chance of hitting.

Colts vs. Rams odds

We have researched the best NFL odds in America for this game, which are listed here:

Bet Type	Colts	Rams
Spread	+3.5 (-105)	-3.5 (-105)
Moneyline	+158	-185
Total	o49.5 (-112)	u49.5 (-105)

All odds are correct at the time of publication and are subject to change.

Boost your NFL betting by exploring the latest NFL betting promos, sourced from top sportsbooks and DFS operators.

Colts vs. Rams picks and best bets

Our model's strongest edge in today's Colts vs. Rams matchup is on the over/under.

Our expert predictions, matched against the latest odds, reveal the best NFL picks and NFL best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Colts vs. Rams TD scorers

Who will score the first touchdown in Colts vs. Rams?

According to our model, Indianapolis' Jonathan Taylor is most likely to score the first touchdown in Colts vs. Rams.

Our projections give Taylor a 14.8% chance of getting in for six first at SoFi Stadium, while the Colts running back is a 57.8% chance of scoring an anytime touchdown.

First touchdown scorer predictions

Indianapolis Colts

Player	First TD Probability
Jonathan Taylor (RB)	14.8%
Daniel Jones (QB)	6.3%
Tyler Warren (TE)	5.5%

Los Angeles Rams

Player	First TD Probability
Kyren Williams (RB)	14.7%
Davante Adams (WR)	9.0%
Puka Nacua (WR)	8.8%

Anytime touchdown scorer predictions

Indianapolis Colts

Player	Anytime TD Probability
Jonathan Taylor (RB)	57.8%
Daniel Jones (QB)	30.8%
Tyler Warren (TE)	27.4%

Los Angeles Rams

Player	Anytime TD Probability
Kyren Williams (RB)	57.5%
Davante Adams (WR)	40.8%
Puka Nacua (WR)	39.9%

Colts vs Rams player props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Colts and Rams. For detailed projections, join Dimers Pro.

Already a Dimers Pro member? Head to our Colts-Rams page now to access every player prop projection.

Colts vs. Rams quarterbacks

Of the starting quarterbacks, the Colts' Daniel Jones is projected to throw for fewer yards than the Rams' Matthew Stafford.

Colts rushing

Jonathan Taylor, Daniel Jones and DJ Giddens are projected to be the leading rushers for the Colts.

Player	Position
Jonathan Taylor	RB
Daniel Jones	QB
DJ Giddens	RB

Rams rushing

Kyren Williams, Blake Corum and Puka Nacua are expected to lead the Rams in rushing yards.

Player	Position
Kyren Williams	RB
Blake Corum	RB
Puka Nacua	WR

Colts receiving

Michael Pittman, Tyler Warren, Josh Downs, Adonai Mitchell and Jonathan Taylor are projected to top the receiving yards for the Colts.

Player	Position
Michael Pittman	WR
Tyler Warren	TE
Josh Downs	WR
Adonai Mitchell	WR
Jonathan Taylor	RB

Rams receiving

Puka Nacua, Davante Adams, Jordan Whittington, Tyler Higbee and Tutu Atwell are projected to lead the Rams in receiving yards.

Player	Position
Puka Nacua	WR
Davante Adams	WR
Jordan Whittington	WR
Tyler Higbee	TE
Tutu Atwell	WR

Colts vs. Rams game-day updates and essential details

The NFL Week 4 matchup between the Rams and Colts at SoFi Stadium is scheduled to start at 4:05PM ET.

• Who: Indianapolis Colts vs. Los Angeles Rams
• Date: Sunday, September 28, 2025
• Time: 4:05PM ET/1:05PM PT
• Venue: SoFi Stadium

Dimers' comprehensive preview of this week's Colts vs. Rams matchup includes our prediction, picks and the latest betting odds.

Before making any Colts vs. Rams picks, be sure to check out the latest NFL predictions and betting advice from Dimers Pro.

NFL Week 4 betting promos and codes

Make the most of Dimers' Colts vs. Rams predictions by exploring the two exciting offers below.

DraftKings Sportsbook

Sign up for DraftKings Sportsbook! Bet $5, get $200 in bonus bets instantly plus over $200 off NFL Sunday Ticket.

Bet365 Sportsbook

Join Bet365 Sportsbook! Bet $5, get $200 in bonus bets win or lose.

Conclusion

We predict the Rams, with a 60% win probability, will likely beat the Colts in Week 4 of the NFL season.

AI and automation have enhanced this article to quickly deliver accurate Colts vs. Rams insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on NFL

Stay up-to-date with the latest NFL news and NFL parlay picks throughout the season. Plus, our Super Bowl odds offer the latest predictions for the Super Bowl, AFC, NFC and each division.