Indiana vs. Iowa prediction: Why Indiana is favored to win in college football Week 5, 2025

Iowa will face the favored Indiana in Week 5 college football action at Kinnick Stadium on Saturday, commencing at 3:30PM ET.

Based on the latest simulations, Dimers' advanced college football model projects Indiana as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Indiana vs. Iowa predictions page.

Indiana vs. Iowa prediction: Who will win, cover the spread?

Using powerful machine learning and data, we have simulated the result of Indiana vs. Iowa 10,000 times as part of our college football predictions coverage.

Our independent predictive model gives Indiana a 73% chance of beating Iowa. Our predicted final score has Indiana winning 29-20.

According to our model, Iowa (+14.5) has a 56% chance of covering the spread, while the 50.5-point over/under has a 58% chance of staying under.

Indiana vs. Iowa odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Indiana	Iowa
Spread	-14.5 (-122)	+14.5 (-108)
Moneyline	-325	+470
Total	o50.5 (-125)	u50.5 (-106)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Indiana vs. Iowa picks and best bets

Our model's biggest edge in today's Indiana vs. Iowa matchup is on the moneyline.

Our expert predictions, aligned with the best odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Indiana vs. Iowa game-day updates and essential details

Saturday's college football matchup between Iowa and Indiana at Kinnick Stadium is scheduled to begin at 3:30PM ET.

• Who: Indiana vs. Iowa
• Date: Saturday, September 27, 2025
• Time: 3:30PM ET/12:30PM PT
• Venue: Kinnick Stadium

Dimers' full preview of Saturday's Indiana vs. Iowa matchup includes our prediction, picks and the latest betting odds.

Before making any Indiana vs. Iowa picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

Conclusion

We predict Indiana, with a 73% win probability, will likely beat Iowa on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Indiana vs. Iowa insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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