Indiana State vs. Indiana prediction: Why Indiana is favored to win in college football Week 3, 2025

Indiana and Indiana State will clash in Week 3 college football action at Memorial Stadium on Friday, with kickoff at 6:30PM ET.

Based on updated simulation results, Dimers' advanced college football model predicts Indiana as the most likely winner of today's game.

For expanded analysis of Friday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Indiana State vs. Indiana predictions page.

Indiana State vs. Indiana prediction: Who will win, cover the spread?

Using trusted machine learning and data, we have simulated the result of Indiana State vs. Indiana 10,000 times as part of our college football predictions coverage.

Our leading predictive model currently gives Indiana a 100% chance of defeating Indiana State. Our predicted final score has Indiana winning 52-5.

According to our model, the bookmakers have got it right, and Indiana State and Indiana each have a 50% chance of covering the spread, while the over/under total of 60.5 points has a 57% chance of going over.

Indiana State vs. Indiana odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	Indiana State	Indiana
Spread	+47.5 (-110)	-47.5 (-110)
Moneyline	+8000	-100000
Total	o60.5 (-110)	u60.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Indiana State vs. Indiana picks and best bets

Our model's biggest edge in today's Indiana State vs. Indiana matchup is on the spread.

Our expert predictions, matched against the best odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Indiana State vs. Indiana game-day updates and essential details

Friday's college football matchup between Indiana and Indiana State at Memorial Stadium is scheduled to begin at 6:30PM ET.

• Who: Indiana State vs. Indiana
• Date: Friday, September 12, 2025
• Time: 6:30PM ET/3:30PM PT
• Venue: Memorial Stadium

Dimers' full preview of Friday's Indiana State vs. Indiana matchup includes our prediction, picks and the latest betting odds.

Before making any Indiana State vs. Indiana picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Indiana, with a 100% win probability, will likely beat Indiana State on Friday.

AI and automation have enhanced this article to quickly deliver accurate Indiana State vs. Indiana insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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