Illinois vs. Indiana prediction: Why Indiana is favored to win in college football Week 4, 2025

Indiana will square off with Illinois in Week 4 college football action at Memorial Stadium on Saturday, commencing at 7:30PM ET.

Based on the latest simulations, Dimers' proven college football model predicts Indiana as the most likely winner of today's game.

For a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Illinois vs. Indiana predictions page.

Illinois vs. Indiana prediction: Who will win, cover the spread?

Using innovative machine learning and data, we have simulated the outcome of Illinois vs. Indiana 10,000 times as part of our college football predictions coverage.

Our leading predictive model gives Indiana a 63% chance of beating Illinois. Our predicted final score has Indiana winning 29-23.

According to our model, Illinois (+6.5) has a 53% chance of covering the spread, while the over/under total of 51.5 points has a 58% chance of staying under.

Illinois vs. Indiana odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	Illinois	Indiana
Spread	+6.5 (-102)	-6.5 (-120)
Moneyline	+205	-250
Total	o51.5 (-108)	u51.5 (-110)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Illinois vs. Indiana picks and best bets

Our model's strongest edge in today's Illinois vs. Indiana matchup is on the spread.

Our expert predictions, aligned with the latest odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Illinois vs. Indiana game-day updates and essential details

Saturday's college football game between Indiana and Illinois at Memorial Stadium is scheduled to start at 7:30PM ET.

• Who: Illinois vs. Indiana
• Date: Saturday, September 20, 2025
• Time: 7:30PM ET/4:30PM PT
• Venue: Memorial Stadium

Dimers' full preview of Saturday's Illinois vs. Indiana matchup includes our prediction, picks and the latest betting odds.

Before making any Illinois vs. Indiana picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

Sports betting deal available for NCAAF Saturday

To make the most of Saturday's exciting day of sports, headlined by clashes like this one for college football Saturday, check out details on the latest Bet365 bonus code "DIMERS" that grants you $200 in bonus bets from a $5 bet — win or lose. Don't miss out!

Conclusion

We predict Indiana, with a 63% win probability, will likely beat Illinois on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Illinois vs. Indiana insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on college football

Stay informed with the latest college football betting news and CFB parlay picks throughout the season. Plus, our College Football National Championship odds offer the most up-to-date predictions for the national title game and major conferences.