Illinois vs. Duke prediction: Illinois favored to win in college football Week 2, 2025

Duke will face Illinois in Week 2 college football action at Brooks Field at Wallace Wade Stadium on Saturday, starting at 12:00PM ET.

Based on updated simulations, Dimers' proven college football model predicts Illinois as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Illinois vs. Duke predictions page.

Illinois vs. Duke prediction: Who will win, cover the spread?

Using powerful machine learning and statistical analysis, we have simulated the result of Illinois vs. Duke 10,000 times as part of our college football predictions coverage.

Our independent predictive model gives Illinois a 52% chance of defeating Duke. Our predicted final score has Illinois winning 25-24.

According to our model, Duke (+2.5) has a 54% chance of covering the spread, while the over/under total of 49.5 points has a 52% chance of staying under.

Illinois vs. Duke odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	Illinois	Duke
Spread	-2.5 (-110)	+2.5 (-110)
Moneyline	-130	+115
Total	o49.5 (-110)	u49.5 (-114)

All odds are correct at the time of publication and are subject to change.

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Illinois vs. Duke picks and best bets

Our model's strongest edge in today's Illinois vs. Duke matchup is on the total.

Our expert predictions, aligned with the latest odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Illinois vs. Duke game-day updates and essential details

Saturday's college football matchup between Duke and Illinois at Brooks Field at Wallace Wade Stadium is scheduled to start at 12:00PM ET.

• Who: Illinois vs. Duke
• Date: Saturday, September 6, 2025
• Time: 12:00PM ET/9:00AM PT
• Venue: Brooks Field at Wallace Wade Stadium

Dimers.com's comprehensive preview of Saturday's Illinois vs. Duke matchup includes our prediction, picks and the latest betting odds.

Before making any Illinois vs. Duke picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Illinois, with a 52% win probability, will likely beat Duke on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Illinois vs. Duke insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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