Illinois State vs. Eastern Illinois prediction: Why Illinois State is favored to win in college football Week 3, 2025

Eastern Illinois and Illinois State will lock horns in Week 3 college football action at O'Brien Field on Saturday, with kickoff at 3:00PM ET.

Based on the latest simulations, Dimers' advanced college football model predicts Illinois State as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Illinois State vs. Eastern Illinois predictions page.

Illinois State vs. Eastern Illinois prediction: Who will win, cover the spread?

Using innovative machine learning and data, we have simulated the outcome of Illinois State vs. Eastern Illinois 10,000 times as part of our college football predictions coverage.

Our leading predictive model currently gives Illinois State a 93% chance of defeating Eastern Illinois. Our predicted final score has Illinois State winning 34-14.

According to our model, Eastern Illinois (+21.5) has a 53% chance of covering the spread, while the over/under total of 50.5 points has a 52% chance of going over.

Illinois State vs. Eastern Illinois odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Illinois State	Eastern Illinois
Spread	-21.5 (-110)	+21.5 (-110)
Moneyline	-1700	+1600
Total	o50.5 (-110)	u50.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Illinois State vs. Eastern Illinois picks and best bets

Our model's strongest edge in today's Illinois State vs. Eastern Illinois matchup is on the moneyline.

Our expert predictions, matched against the best odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Illinois State vs. Eastern Illinois game-day updates and essential details

Saturday's college football game between Eastern Illinois and Illinois State at O'Brien Field is scheduled to begin at 3:00PM ET.

• Who: Illinois State vs. Eastern Illinois
• Date: Saturday, September 13, 2025
• Time: 3:00PM ET/12:00PM PT
• Venue: O'Brien Field

Dimers' comprehensive preview of Saturday's Illinois State vs. Eastern Illinois matchup includes our prediction, picks and the latest betting odds.

Before making any Illinois State vs. Eastern Illinois picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Illinois State, with a 93% win probability, will likely beat Eastern Illinois on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Illinois State vs. Eastern Illinois insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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