Houston vs. Oregon State prediction: Houston favored to win in college football Week 5, 2025

Oregon State will square off with the favored Houston in Week 5 college football action at Reser Stadium on Friday, beginning at 10:30PM ET.

Based on updated simulation results, Dimers' advanced college football model predicts Houston as the most likely winner of today's game.

For expanded analysis of Friday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Houston vs. Oregon State predictions page.

Houston vs. Oregon State prediction: Who will win, cover the spread?

Using trusted machine learning and data, we have simulated the outcome of Houston vs. Oregon State 10,000 times as part of our college football predictions coverage.

Our independent predictive model currently gives Houston an 82% chance of beating Oregon State. Our predicted final score has Houston winning 29-17.

According to our model, Houston (-10.5) has a 52% chance of covering the spread, while the 44.5-point over/under has a 54% chance of going over.

Houston vs. Oregon State odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Houston	Oregon State
Spread	-10.5 (-115)	+10.5 (-110)
Moneyline	-410	+375
Total	o44.5 (-108)	u44.5 (-122)

All odds are correct at the time of publication and are subject to change.

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Houston vs. Oregon State picks and best bets

Our model's biggest edge in today's Houston vs. Oregon State matchup is on the spread.

Our expert predictions, matched against the best odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Houston vs. Oregon State game-day updates and essential details

Friday's college football matchup between Oregon State and Houston at Reser Stadium is scheduled to start at 10:30PM ET.

• Who: Houston vs. Oregon State
• Date: Friday, September 26, 2025
• Time: 10:30PM ET/7:30PM PT
• Venue: Reser Stadium

Dimers' full preview of Friday's Houston vs. Oregon State matchup includes our prediction, picks and the latest betting odds.

Before making any Houston vs. Oregon State picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

Conclusion

We predict Houston, with an 82% win probability, will likely beat Oregon State on Friday.

AI and automation have enhanced this article to quickly deliver accurate Houston vs. Oregon State insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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