Astros vs. Blue Jays prediction: Why Toronto is favored to win Wednesday's MLB matchup [9/10/2025]

MLB action continues on Wednesday at 7:07PM ET as the Houston Astros take on the Toronto Blue Jays at Rogers Centre.

José Berríos (9-5, 4.02 ERA) will be on the bump for the Blue Jays, pitting him against Jason Alexander (4-1, 4.68 ERA) for the Astros.

Based on updated simulations, Dimers' proven MLB model projects the Blue Jays as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Astros-Blue Jays game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Blue Jays' chance of winning at 56%, with the Astros at 44%."

For further insights into Wednesday's matchup, including best bets and picks, visit our interactive Astros vs. Blue Jays predictions page.

Blue Jays vs. Astros prediction: Who will win, cover the run line?

Using powerful machine learning and data, we have simulated the result of Wednesday's MLB game between the Astros and Blue Jays 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Blue Jays a 56% chance of defeating the Astros.

According to our model, the Astros (+1.5) have a 61% chance of covering the run line, while the over/under total of 8.5 runs has a 56% chance of going over.

Astros vs. Blue Jays odds [9/10/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Astros	Blue Jays
Run Line	+1.5 (-155)	-1.5 (+135)
Moneyline	+135	-155
Total	o8.5 (-118)	u8.5 (+100)

All odds are correct at the time of publication and are subject to change.

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Astros vs. Blue Jays picks and best bets

Our model's biggest edge in today's Astros vs. Blue Jays matchup is on the run line.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets video

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Astros vs. Blue Jays game-day updates and essential details

Wednesday's MLB action between the Blue Jays and Astros at Rogers Centre is scheduled to start at 7:07PM ET.

• Who: Houston Astros vs. Toronto Blue Jays
• Date: Wednesday, September 10, 2025
• Time: 7:07PM ET/4:07PM PT
• Venue: Rogers Centre

Dimers' in-depth preview of Wednesday's Astros vs. Blue Jays matchup includes our prediction, picks and the latest betting odds.

Before making any Astros vs. Blue Jays picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Blue Jays, with a 56% win probability, will likely beat the Astros on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Astros vs. Blue Jays insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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