Astros vs. Rays Prediction: Houston Predicted to Win Wednesday's MLB Matchup [5/21/2025]

The Tampa Bay Rays will square off with the Houston Astros in MLB action at George M. Steinbrenner Field on Wednesday, beginning at 1:10PM ET.

Taj Bradley (3-3, 4.80 ERA) will get the ball for the Rays, while the Astros have opted for Hunter Brown (6-2, 1.43 ERA).

Based on the latest simulation results, Dimers' proven MLB model (see Dimers Pro for full access) projects the Astros as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Houston-Tampa Bay game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Astros' chance of winning at 58%, with the Rays at 42%."

For a closer look at Wednesday's matchup, including best bets and picks, visit our interactive Astros vs. Rays predictions page.

Rays vs. Astros Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data, we have simulated the result of Wednesday's MLB game between the Astros and Rays 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Astros a 58% chance of beating the Rays.

According to our model, the Rays (+1.5) have a 56% chance of covering the run line, while the over/under total of 8.5 runs has a 53% chance of staying under.

Astros vs. Rays Odds [5/21/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Astros	Rays
Run Line	-1.5 (+110)	+1.5 (-110)
Moneyline	-148	+142
Total	o8.5 (-110)	u8.5 (-102)

All odds are correct at the time of publication and are subject to change.

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Astros vs. Rays Picks and Best Bets

Our model's biggest edge in today's Astros vs. Rays matchup is on the total.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Astros vs. Rays Game-Day Updates and Essential Details

Wednesday's MLB matchup between the Rays and Astros at George M. Steinbrenner Field is scheduled to start at 1:10PM ET.

• Who: Houston Astros vs. Tampa Bay Rays
• Date: Wednesday, May 21, 2025
• Time: 1:10PM ET/10:10AM PT
• Venue: George M. Steinbrenner Field

Dimers.com's in-depth preview of Wednesday's Astros vs. Rays matchup includes our prediction, picks and the latest betting odds.

Before making any Houston vs. Tampa Bay picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Astros, with a 58% win probability, will likely beat the Rays on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Astros vs. Rays insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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