Astros vs. Cardinals Prediction: Houston Predicted to Win Tuesday's MLB Matchup [4/15/2025]

The St. Louis Cardinals and Houston Astros are scheduled to meet in MLB action at Busch Stadium on Tuesday, starting at 7:45PM ET.

Erick Fedde (1-1, 4.20 ERA) will get the ball for the Cardinals, up against Hunter Brown (1-1, 2.00 ERA) for the Astros.

Based on updated simulations, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Astros as the most likely winner of today's game.

"Our team has analyzed the latest data and conducted 10,000 simulations for Tuesday's Houston-St. Louis game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various factors, our prediction shows the Astros with a win probability of 55%, compared to 45% for the Cardinals."

For further insights into Tuesday's matchup, including best bets and picks, visit our interactive Astros vs. Cardinals predictions page.

Astros vs. Astros Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data, we have simulated the result of Tuesday's MLB game between the Astros and Cardinals 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Astros a 55% chance of beating the Cardinals.

According to our model, the Cardinals (+1.5) have a 59% chance of covering the run line, while the 7.5-run over/under has a 51% chance of going over.

Astros vs. Cardinals Odds [4/15/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Astros	Cardinals
Run Line	-1.5 (+140)	+1.5 (-152)
Moneyline	-130	+116
Total	o7.5 (-102)	u7.5 (-115)

All odds are correct at the time of publication and are subject to change.

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Astros vs. Cardinals Picks and Best Bets

Our model's strongest edge in today's Astros vs. Cardinals matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Astros vs. Cardinals Game-Day Updates and Essential Details

Tuesday's MLB matchup between the Cardinals and Astros at Busch Stadium is scheduled to begin at 7:45PM ET.

• Who: Houston Astros vs. St. Louis Cardinals
• Date: Tuesday, April 15, 2025
• Time: 7:45PM ET/4:45PM PT
• Venue: Busch Stadium

Dimers.com's comprehensive preview of Tuesday's Astros vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any Houston vs. St. Louis picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Astros, with a 55% win probability, will likely beat the Cardinals on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Astros vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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