Astros vs. Pirates Prediction: Houston Predicted to Win Wednesday's MLB Matchup [6/4/2025]

The Pittsburgh Pirates will face the Houston Astros in MLB action at PNC Park on Wednesday, commencing at 6:40PM ET.

Mike Burrows (0-1, 8.64 ERA) will start for the Pirates, up against Ryan Gusto (3-2, 4.62 ERA) for the Astros.

Based on updated simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Astros as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Houston-Pittsburgh game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Astros' chance of winning at 53%, with the Pirates at 47%."

For expanded analysis of Wednesday's matchup, including best bets and picks, visit our interactive Astros vs. Pirates predictions page.

Pirates vs. Astros Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data, we have simulated the result of Wednesday's MLB game between the Astros and Pirates 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Astros a 53% chance of defeating the Pirates.

According to our model, the Pirates (+1.5) have a 59% chance of covering the run line, while the over/under total of 9 runs has a 53% chance of staying under.

Astros vs. Pirates Odds [6/4/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Astros	Pirates
Run Line	-1.5 (+125)	+1.5 (-146)
Moneyline	-126	+110
Total	o9 (-110)	u9 (-102)

All odds are correct at the time of publication and are subject to change.

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Astros vs. Pirates Picks and Best Bets

Our model's strongest edge in today's Astros vs. Pirates matchup is on the run line.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Astros vs. Pirates Game-Day Updates and Essential Details

Wednesday's MLB game between the Pirates and Astros at PNC Park is scheduled to start at 6:40PM ET.

• Who: Houston Astros vs. Pittsburgh Pirates
• Date: Wednesday, June 4, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: PNC Park

Dimers.com's comprehensive preview of Wednesday's Astros vs. Pirates matchup includes our prediction, picks and the latest betting odds.

Before making any Houston vs. Pittsburgh picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Astros, with a 53% win probability, will likely beat the Pirates on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Astros vs. Pirates insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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