Astros vs. Pirates Prediction: Houston Predicted to Win Thursday's MLB Matchup [6/5/2025]

MLB action continues on Thursday at 6:40PM ET as the Houston Astros square off with the Pittsburgh Pirates at PNC Park.

The Pirates will send Mitch Keller (1-7, 3.73 ERA) to the mound, up against Framber Valdez (5-4, 3.12 ERA) for the Astros.

Based on the latest simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Astros as the most likely winner of today's game.

"Using the latest data, our experts simulated Thursday's Houston-Pittsburgh game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Taking into account recent updates and various additional inputs, we forecast the Astros with a win probability of 56% and the Pirates with 44%."

For a closer look at Thursday's matchup, including best bets and picks, visit our interactive Astros vs. Pirates predictions page.

Pirates vs. Astros Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data, we have simulated the outcome of Thursday's MLB game between the Astros and Pirates 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Astros a 56% chance of beating the Pirates.

According to our model, the Pirates (+1.5) have a 57% chance of covering the run line, while the 7.5-run over/under has a 52% chance of staying under.

Astros vs. Pirates Odds [6/5/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Astros	Pirates
Run Line	-1.5 (+120)	+1.5 (-137)
Moneyline	-140	+122
Total	o7.5 (+102)	u7.5 (-112)

All odds are correct at the time of publication and are subject to change.

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Astros vs. Pirates Picks and Best Bets

Our model's biggest edge in today's Astros vs. Pirates matchup is on the run line.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Today

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Astros vs. Pirates Game-Day Updates and Essential Details

Thursday's MLB game between the Pirates and Astros at PNC Park is scheduled to start at 6:40PM ET.

• Who: Houston Astros vs. Pittsburgh Pirates
• Date: Thursday, June 5, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: PNC Park

Dimers.com's full preview of Thursday's Astros vs. Pirates matchup includes our prediction, picks and the latest betting odds.

Before making any Houston vs. Pittsburgh picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Astros, with a 56% win probability, will likely beat the Pirates on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Astros vs. Pirates insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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