Astros vs. Angels prediction: Houston favored to win Sunday's MLB matchup [9/28/2025]

The Los Angeles Angels will square off with the Houston Astros in MLB action at Angel Stadium on Sunday, commencing at 3:07PM ET.

Sam Aldegheri (0-1, 8.00 ERA) will be the starting pitcher for the Angels, while the Astros have opted for Lance McCullers (2-5, 6.71 ERA).

Based on updated simulations, Dimers' proven MLB model projects the Astros as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Astros-Angels game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Astros with a win probability of 53%, while the Angels have 47%."

For further insights into Sunday's matchup, including best bets and picks, visit our interactive Astros vs. Angels predictions page.

Angels vs. Astros prediction: Who will win, cover the run line?

Using innovative machine learning and data, we have simulated the outcome of Sunday's MLB matchup between the Astros and Angels 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Astros a 53% chance of defeating the Angels.

According to our model, the Angels (+1.5) have a 57% chance of covering the run line, while the 9-run over/under has a 60% chance of going over.

Astros vs. Angels odds [9/28/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Astros	Angels
Run Line	-1.5 (+136)	+1.5 (-164)
Moneyline	-116	+100
Total	o9 (+100)	u9 (-115)

All odds are correct at the time of publication and are subject to change.

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Astros vs. Angels picks and best bets

Our model's strongest edge in today's Astros vs. Angels matchup is on the run line.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets

Calling Our Shot produces daily MLB betting content, including the free picks featured below.

Astros vs. Angels game-day updates and essential details

Sunday's MLB game between the Angels and Astros at Angel Stadium is scheduled to commence at 3:07PM ET.

• Who: Houston Astros vs. Los Angeles Angels
• Date: Sunday, September 28, 2025
• Time: 3:07PM ET/12:07PM PT
• Venue: Angel Stadium

Dimers' in-depth preview of Sunday's Astros vs. Angels matchup includes our prediction, picks and the latest betting odds.

Before making any Astros vs. Angels picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Astros, with a 53% win probability, will likely beat the Angels on Sunday.

AI and automation have enhanced this article to quickly deliver accurate Astros vs. Angels insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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