Astros vs. Angels prediction: Houston favored to win Friday's MLB matchup [9/26/2025]

The Los Angeles Angels will face the Houston Astros in MLB action at Angel Stadium on Friday, beginning at 9:38PM ET.

The Angels will have Kyle Hendricks (8-10, 4.79 ERA) as their starting pitcher, up against Jason Alexander (4-2, 4.83 ERA) for the Astros.

Based on updated simulation results, Dimers' proven MLB model predicts the Astros as the most likely winner of today's game.

For expanded analysis of Friday's matchup, including best bets and picks, visit our interactive Astros vs. Angels predictions page.

Angels vs. Astros prediction: Who will win, cover the run line?

Using innovative machine learning and statistical analysis, we have simulated the result of Friday's MLB matchup between the Astros and Angels 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Astros a 56% chance of beating the Angels.

According to our model, the Angels (+1.5) have a 55% chance of covering the run line, while the 9-run over/under has a 57% chance of going over.

Astros vs. Angels odds [9/26/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Astros	Angels
Run Line	-1.5 (+125)	+1.5 (-142)
Moneyline	-132	+115
Total	o9 (-105)	u9 (-110)

All odds are correct at the time of publication and are subject to change.

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Astros vs. Angels picks and best bets

Our model's strongest edge in today's Astros vs. Angels matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets video

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Astros vs. Angels game-day updates and essential details

Friday's MLB matchup between the Angels and Astros at Angel Stadium is scheduled to begin at 9:38PM ET.

• Who: Houston Astros vs. Los Angeles Angels
• Date: Friday, September 26, 2025
• Time: 9:38PM ET/6:38PM PT
• Venue: Angel Stadium

Dimers' full preview of Friday's Astros vs. Angels matchup includes our prediction, picks and the latest betting odds.

Before making any Astros vs. Angels picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Astros, with a 56% win probability, will likely beat the Angels on Friday.

AI and automation have enhanced this article to quickly deliver accurate Astros vs. Angels insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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